0000000000939902

AUTHOR

D. Guyonnet

showing 5 related works from this author

Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction

2001

In a previous study, we showed that naturally occurring organosulfur compounds (OSCs) from garlic and onion modulated the activation of carcinogen via the alteration of cytochromes P450. The present study was undertaken to determine the incidence of the in vivo induction of phase II enzymes by individual OSCs on the genotoxicity of several carcinogens. Diallyl sulfide (DAS), diallyl disulfide (DADS), dipropyl sulfide (DPS) and dipropyl disulfide (DPDS), were administered by gavage (1mmol/kg) to male SPF Wistar rats for 4 consecutive days. The effects of treatments on phase II enzymes and on the genotoxicity of carcinogens were evaluated with hepatic cytosols and microsomes from OSCs-treated…

MaleSalmonella typhimuriumHealth Toxicology and Mutagenesis[SDV]Life Sciences [q-bio]Allyl compoundAdministration OralSulfidesmedicine.disease_causeAmes testAllium03 medical and health scienceschemistry.chemical_compoundPropane0302 clinical medicineGeneticsmedicineNAD(P)H Dehydrogenase (Quinone)AnimalsDisulfidesRats WistarEpoxide hydrolaseCarcinogenComputingMilieux_MISCELLANEOUS030304 developmental biologyGlutathione TransferaseEpoxide Hydrolases0303 health sciencesDose-Response Relationship DrugChemistryDiallyl disulfideMutagenicity TestsAntimutagenic Agents3. Good healthRatsSpecific Pathogen-Free Organisms[SDV] Life Sciences [q-bio]Allyl CompoundsBiochemistryAntimutagenic AgentsLiver030220 oncology & carcinogenesisEnzyme InductionAntimutagenGenotoxicityMutagensSubcellular Fractions
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Liver subcellular fractions from rats treated by organosulfur compounds from Allium modulate mutagen activation

2000

The effects of in vivo administration of naturally occurring organosulfur compounds (OSCs) from Allium species were studied on the activation of several mutagens. Male SPF Wistar rats were given p.o. one of either diallyl sulfide (DAS), diallyl disulfide (DADS), dipropyl sulfide (DPS) or dipropyl disulfide (DPDS) during 4 consecutive days and the ability of hepatic S9 and microsomes from treated rats to activate benzo[a]pyrene (BaP), cyclophosphamide (CP), dimethylnitrosamine (DMN), N-nitrosopiperidine (N-PiP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was determined in the Ames test. Administration of DAS, DPS and DPDS resulted in a significant increase of the activation of…

MaleNitrosaminesHealth Toxicology and Mutagenesis[SDV]Life Sciences [q-bio]MutagenSulfidesmedicine.disease_causeIsozymeAlliumDimethylnitrosamineAmes testPropane03 medical and health scienceschemistry.chemical_compound0302 clinical medicineCytochrome P-450 Enzyme SystemBenzo(a)pyreneCytochrome P-450 CYP1A1GeneticsmedicineAnimalsDisulfidesRats WistarCyclophosphamideComputingMilieux_MISCELLANEOUS030304 developmental biology0303 health sciencesDose-Response Relationship DrugMutagenicity TestsDiallyl disulfideImidazolesCytochrome P-450 CYP2E1CYP2E1RatsAllyl Compounds[SDV] Life Sciences [q-bio]Dose–response relationshipBiochemistrychemistry030220 oncology & carcinogenesisCytochrome P-450 CYP2B1ToxicityMicrosomes LiverMicrosomeLiver ExtractsOxidoreductasesMutagensSubcellular Fractions
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Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis

2004

Effects of administration of diallyl sulfide (DAS) and diallyl disulfide (DADS) on the promotion stage of hepatocarcinogenesis were investigated in rats using the Ito model. They were compared with those of phenobarbital (PB), a well-known liver promoter in rats. Initiation was induced by a single dose of N-nitrosodiethylamine (NDEA) and 3 weeks later, a partial hepatectomy was conducted. Two weeks after the NDEA injection, rats received either 0.05% allyl sulfides, PB or both in their diet for 8 weeks. Feeding with DAS increased the number of liver preneoplastic foci by 63% with respect to the untreated group. However, rats fed DAS showed a lower foci development than rats fed PB. The DADS…

Malemedicine.medical_treatment[SDV]Life Sciences [q-bio]Toxicologymedicine.disease_causechemistry.chemical_compound0302 clinical medicineLiver Neoplasms ExperimentalDiethylnitrosamineDrug InteractionsDisulfidesComputingMilieux_MISCELLANEOUS0303 health sciencesDiallyl disulfideGeneral MedicineCANCER3. Good healthSpecific Pathogen-Free OrganismsAllyl Compounds[SDV] Life Sciences [q-bio]BiochemistryDiallyl sulfide030220 oncology & carcinogenesismedicine.drugmedicine.medical_specialtySulfidesDIALLYL DISULFITEChemopreventionPreneoplastic foci03 medical and health sciencesInternal medicinemedicineAnimalsAnticarcinogenic AgentsHepatectomyDIALLYL SULFITERats Wistar030304 developmental biologyRatsEndocrinologychemistryRat liverCarcinogensRATPhenobarbitalHepatectomyCarcinogenesisAllyl SulfidePrecancerous ConditionsFood Science
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Mechanisms of protection against aflotoxin B1 genotoxycity in rats treated by organosulfur compounds from garlic

2002

International audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]CANCERIGENERATDIALLYL DISULFITEAFLOTOXINE B1ComputingMilieux_MISCELLANEOUS
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Modulation of phase II enzymes by organosulfur compounds from allium vegetables in rat tissues

1999

International audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]RATTECHNIQUE DES TRACEURSCYTOCHROME P 450ComputingMilieux_MISCELLANEOUS
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