0000000000940502
AUTHOR
L Parnell
SEQPACKER: A Biologist-Friendly User Interface to Manipulate Nucleotide Sequences in Genomic Epidemiology
The aim of this paper is to present a new integrated bioinformatics tool for manipulating nucleotide sequences with a user-friendly graphical interface. This tool is named “SeqPacker” because it uses DNA/RNA sequences. In addition, SeqPacker can be seen as a kind of nucleotide chain editor using standardized technologies, nucleotide representation standards, and high platform portability in support of research in Genomic Epidemiology. SeqPacker is written in JAVA as free and stand-alone software for several computer platforms.
EPIGENOMICS AND METABOLOMICS MECHANISMS FOR A GENE X DIET INTERACTION MODULATING AGE-RELATED OBESITY
A functional variant in the apolipoprotein AII (APOA2) gene (rs5082) predisposes homozygous carriers to age-related obesity when habitual saturated fat (SFA) intake is high. We used epigenomics, transcription and metabolomics analyses to identify currently unknown mechanisms underlying this well-replicated gene x diet interaction. We conducted an epigenome-wide scan to compare genetically at-risk to low-risk individuals with low (<22 g/d) or high (≥22 g/d) SFA intake in the Boston Puerto Rican Health Study and validated the findings in the GOLDN Study and the Framingham Heart Study. In these three populations, we identified genotype-dependent differential methylation, only with high SFA int…