HSP10,HSP70 AND HSP90 IMMUNOHISTOCHEMICAL LEVELS CHANGE IN ULCERATIVE COLITIS AFTER THERAPY

Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal Hsp60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat shock protein/molecular chaperones:…

The impact of the patient's Adjustment to breast cancer of the burden and distress of the caregiver.

Terapia medica e supporto psicologico in un gruppo di pazienti affette da carcinoma mammario

62 THE ROLE OF PSYCHOLOGICAL ASPECTS IN ONCOGENETIC COUNSELLING

Risk Perception and Psychological Distress in Genetic Counselling for Hereditary Breast and/or Ovarian Cancer

International audience; Oncological Genetic Counselling (CGO) allows the identification of a genetic component that increases the risk of developing a cancer. Individuals' psychological reactions are influenced by both the content of the received information and the subjective perception of their own risk of becoming ill or being a carrier of a genetic mutation. This study included 120 participants who underwent genetic counselling for breast and/or ovarian cancer. The aim of the study was to examine the relation between their cancer risk perception and the genetic risk during CGO before receiving genetic test results, considering the influence of some psychological variables, in particular…

THE ROLE OF PSYCHOLOGICAL ASPECTS IN ONCOGENETIC COUNSELLING

Background: As result of the recent developments in DNA testing and the knowledge that cancer can be hereditary, it is now possible to offer genetic counselling to people within identified “cancer families”, and to inform them about their assumed increased risk for developing cancer. The aim of this study was to test the role of psychological aspect in oncogenetic counselling. The primary purpose of the research was to evaluate the difference between Anxiety Trait and Anxiety State in subjects going to oncogenetic counselling. The secondary aim was to explore the relationships between alexithymia, personality trait, coping style, psychological distress, in subjects attending genetic counsel…

WELL-BEING, SOURCES OF STRESS AND COPING STRATEGIES IN A SAMPLE OF ONCOLOGISTS

Background: Several studies have highlighted that some professional categories, called: ‘helping professions’, appear, more than other professions, to be subjected to sources of stress and the connected risks of burn-out. In particular personnel working in oncology face potentially stressful situations and having to deal daily with the needs and concerns of the patients and their families. It is therefore necessary to understand the variables that can limit the impact of stress. This research seeks to explore the degree of personal well-being of the oncologists interviewed, taking into consideration some possible predictors, such as the age and specific trainings (i.e. in diagnosis communic…

Nivolumab in metastatic melanoma: good efficacy and tolerability in elderly patients.

Nivolumab is an anti&ndash