0000000000949256

AUTHOR

Oliver Rickes

showing 3 related works from this author

Daily oscillation of gene expression in the retina is phase-advanced with respect to the pineal gland

2007

Abstract The photoreceptive retina and the non-photoreceptive pineal gland are components of the circadian and the melatonin forming system in mammals. To contribute to our understanding of the functional integrity of the circadian system and the melatonin forming system we have compared the daily oscillation of the two tissues under various seasonal lighting conditions. For this purpose, the 24-h profiles of the expression of the genes coding for arylalkylamine N-acetyltransferase (AA-NAT), nerve growth factor inducible gene-A (NGFI-A), nerve growth factor inducible gene-B (NGFI-B), retinoic acid related orphan receptor β (RORβ), dopamine D4 receptor, and period2 (Per2) have been simultane…

Maleendocrine systemmedicine.medical_specialtyGene ExpressionCell Cycle ProteinsBiologyArylalkylamine N-AcetyltransferasePineal GlandRetinaPinealocyteRats Sprague-DawleyMelatoninPineal glandInternal medicinemedicineAnimalsCircadian rhythmMolecular BiologyEarly Growth Response Protein 1RetinaSuprachiasmatic nucleusGeneral NeuroscienceReceptors Dopamine D4Nuclear ProteinsPeriod Circadian ProteinsMicroarray AnalysisCircadian RhythmRatsPER2Endocrinologymedicine.anatomical_structureFemaleNeurology (clinical)Developmental BiologyEndocrine glandmedicine.drugBrain Research
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Phosphodiesterase 10A in the Rat Pineal Gland: Localization, Daily and Seasonal Regulation of Expression and Influence on Signal Transduction

2010

The cyclic nucleotide phosphodiesterase 10A (PDE10A) is highly expressed in striatal spiny projection neurons and represents a therapeutic target for the treatment of psychotic symptoms. As reported previously [J Biol Chem 2009; 284:7606–7622], in this study PDE10A was seen to be additionally expressed in the pineal gland where the levels of PDE10A transcript display daily changes. As with the transcript, the amount of PDE10A protein was found to be under daily and seasonal regulation. The observed cyclicity in the amount of PDE10A mRNA persists under constant darkness, is blocked by constant light and is modulated by the lighting regime. It therefore appears to be driven by the master cloc…

Malemedicine.medical_specialtyAANATPhosphodiesterase InhibitorsEndocrinology Diabetes and MetabolismBlotting WesternBiologyReal-Time Polymerase Chain ReactionPineal GlandRats Sprague-DawleyCellular and Molecular NeurosciencePineal glandEndocrinologyOrgan Culture TechniquesInternal medicinePapaverinemedicineCyclic AMPAnimalsImmunoprecipitationProtein kinase A signalingCyclic GMPDNA PrimersPhosphodiesterase 10A;Circadian system;Pineal gland;Norepinephrine;cAMP;cGMP;Arylalkylamine N-acetyltransferaseEndocrine and Autonomic SystemsSuprachiasmatic nucleusPhosphoric Diester HydrolasesPhosphodiesteraseImmunohistochemistryCircadian RhythmRatsddc:medicine.anatomical_structureEndocrinologySecond messenger systemRNAFemaleSuprachiasmatic NucleusPDE10ASeasonsSignal transductionAdrenergic alpha-AgonistsSignal Transduction
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Phosphodiesterase10A: abundance and circadian regulation in the retina and photoreceptor of the rat.

2011

Phosphodiesterase10A (PDE10A) is a dual specific cyclic nucleotide phosphodiesterase that is specifically enriched in striatum and which has gained attention as a therapeutic target for psychiatric disorders. The present study shows that PDE10A is also highly expressed in retinal neurons including photoreceptors. The levels of PDE10A transcript and protein display daily rhythms which could be seen in preparations of the whole retina. Corresponding changes in PDE10A mRNA were seen in photoreceptors isolated using laser microdissection. This suggests that the expressional control of the photoreceptor Pde10a gene contributes to the observed cyclicity in the amount of retinal PDE10A. The daily …

medicine.medical_specialtygenetic structuresAANATBlotting WesternContext (language use)Biologychemistry.chemical_compoundCyclic nucleotideInternal medicinemedicineAnimalsImmunoprecipitationCircadian rhythmRNA MessengerMolecular BiologyLaser capture microdissectionRetinaMicroscopy ConfocalPhosphoric Diester HydrolasesReverse Transcriptase Polymerase Chain ReactionGeneral NeuroscienceLasersRetinalCell biologyCircadian RhythmRatsLight intensityEndocrinologymedicine.anatomical_structurechemistrysense organsNeurology (clinical)Nucleotides CyclicMicrodissectionDevelopmental BiologyPhotoreceptor Cells VertebrateBrain research
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