0000000000950234

AUTHOR

Sm Schwartz

showing 3 related works from this author

Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 coun…

2015

Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the eff ectiveness of health systems, and to inform global policy on cancer control. Methods Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15–99 years) and 75 000 children (age 0–14 years) diagnosed with cancer during 1995–2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardise…

Maleeurope 1999-2007PathologyCàncer -- EstadístiquesSurvival[SDV]Life Sciences [q-bio]2700 General MedicineGlobal HealthSettore MED/42 - Igiene Generale E ApplicataNeoplasms80 and overGlobal healthRegistriesStomach cancerChildcancer survivalBreast-cancerComputingMilieux_MISCELLANEOUScancer registry; cancer survival; worldwideCervical cancerAged 80 and overeducation.field_of_studychildhood-cancerMedicine (all)1. No povertyGeneral Medicinecancer survival; population-based registries; surveillanceMiddle Aged3. Good healthovarian-cancerChild Preschoolpopulation-based registriesurveillance/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemalenet survivalNeoplasms/mortalityBreast-cancer; childhood-cancer; rectal-cancer; nordic countries; europe 1999-2007; ovarian-cancer; net survival; data quality; care; stageAdultmedicine.medical_specialtyAdolescentPopulationSocio-culturale610 Medicine & healthAdolescent; Adult; Age Distribution; Aged; Aged 80 and over; Child; Child Preschool; Female; Global Health; Humans; Infant; Infant Newborn; Male; Middle Aged; Neoplasms; Registries; Sex Distribution; Survival Analysis; Young Adult; Medicine (all)Articlerectal-cancerYoung AdultBreast cancerAge DistributionSDG 3 - Good Health and Well-beingcancer survival; cancer registriesmedicinedata qualityHumanscareSex DistributionPreschooleducationSupervivèncianordic countriesSurvival analysisddc:613AgedCancer -- Statisticsbusiness.industryInfant NewbornCancerInfant10060 Epidemiology Biostatistics and Prevention Institute (EBPI)Newbornmedicine.diseasestageSurvival AnalysisCancer registrycancer registriesbusinessDemography
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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

2011

1. The CARDIoGRAM Consortium. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 2011;43:333–338. ### Study Hypothesis Recently, genome-wide association studies (GWAS) have identified several common variants that are associated with risk of coronary artery disease (CAD) and myocardial infarction (MI). The authors state that the current loci discovered in CAD and MI GWAS explain only a small fraction of the heritability of this complex disease. The authors hypothesized that a larger study would provide more power to discover common variants with modest effect sizes. Therefore, they formed the Coronary ARtery DIsease Genome-wid…

AdultMaleMultifunction cardiogramLocus (genetics)Single-nucleotide polymorphismGenome-wide association studyCoronary Artery DiseaseBiologyPolymorphism Single NucleotideGenetic determinismartery diseaseArticleCoronary artery diseaseGene FrequencySDG 3 - Good Health and Well-beingRisk FactorsGeneticsmedicineHumansGenetic Predisposition to Diseasecardiovascular diseasesAlleleGenotypingAllele frequencycoronaryAllelesGenetics (clinical)AgedGenetic associationGeneticsbusiness.industrycoronary; artery diseaseCase-control studyMiddle Agedmedicine.diseasecoronary artery disease; Large-scale association analysisCase-Control StudiesFemaleCardiology and Cardiovascular MedicinebusinessGenome-Wide Association Study
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Large-scale gene-centric analysis identifies novel variants for coronary artery disease.

2011

Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through w…

MaleCancer ResearchCandidate geneEpidemiologyGenome-wide association studyCoronary Artery Disease030204 cardiovascular system & hematologyCardiovascular0302 clinical medicineGENETICS & HEREDITYGenetics (clinical)Genetics0303 health sciencesCardiovascular diseases [NCEBP 14]Middle Aged3. Good healthCYP17A1Genetic EpidemiologyGenome-wide association; Myocardial-infarction; Susceptibility loci; Risk; Atherosclerosis; Metanalysis; LipoproteinMedicineFemaleLife Sciences & BiomedicineResearch ArticleAsian Continental Ancestry GroupAdultRiskSUSCEPTIBILITY LOCIlcsh:QH426-470European Continental Ancestry GroupBiologyPolymorphism Single Nucleotidecoronary artery disease; geneticsWhite People03 medical and health sciencesSDG 3 - Good Health and Well-beingAsian PeopleGenetic variationGeneticsHumansGenetic Predisposition to DiseaseGENOME-WIDE ASSOCIATIONAlleleMolecular BiologyGeneBiologyMETAANALYSISEcology Evolution Behavior and SystematicsGenetic Association StudiesCardiovascular Disease EpidemiologyAlleles030304 developmental biologyAged0604 GeneticsScience & TechnologyCase-control studyGenetic VariationHuman GeneticsOdds ratiolarge-scale gene analysiscoronary artery disease; large-scale gene analysislcsh:GeneticsLIPOPROTEINMYOCARDIAL-INFARCTIONATHEROSCLEROSISCase-Control StudiesGenetics of DiseaseIBC 50K CAD ConsortiumDevelopmental BiologyGenome-Wide Association Study
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