In silico pace-mapping: prediction of left vs. right outflow tract origin in idiopathic ventricular arrhythmias with patient-specific electrophysiological simulations

Abstract Aims A pre-operative non-invasive identification of the site of origin (SOO) of outflow tract ventricular arrhythmias (OTVAs) is important to properly plan radiofrequency ablation procedures. Although some algorithms based on electrocardiograms (ECGs) have been developed to predict left vs. right ventricular origins, their accuracy is still limited, especially in complex anatomies. The aim of this work is to use patient-specific electrophysiological simulations of the heart to predict the SOO in OTVA patients. Methods and results An in silico pace-mapping procedure was designed and used on 11 heart geometries, generating for each case simulated ECGs from 12 clinically plausible SOO…

A rule‐based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts

Rule-based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from rule-based methods often does not match histological data in other areas of the heart such as the right ventricle, having a negative impact in cardiac simulations beyond the left ventricle. In this work, we present a rule-based method where fiber orientation is separately modeled in each ventricle following observations from histology. This allows to create detailed fiber orientation in specific regions such as the endocardium of the right ventricle, the inter…

87Non-invasive virtual prediction of site of origin in outflow tract ventricular arrhythmias with a patient-specific computational model

A Rule-Based Method to Model Myocardial Fiber Orientation for Simulating Ventricular Outflow Tract Arrhythmias

Comunicació presentada a: FIMH 2017 9th International Conference, celebrada a Toronto, Canadà, de l'11 al 13 de juny de 2017. Myocardial fiber orientation determines the propagation of electrical waves in the heart and the contraction of cardiac tissue. One common approach for assigning fiber orientation to cardiac anatomi- cal models are Rule-Based Methods (RBM). However, RBM have been developed to assimilate data mostly from the Left Ventricle. In conse- quence, fiber information from RBM does not match with histological data in other areas of the heart, having a negative impact in cardiac simulations beyond the LV. In this work, we present a RBM where fiber orientation is separately mode…

Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias

In order to determine the site of origin (SOO) in outflow tract ventricular arrhythmias (OTVAs) before an ablation procedure, several algorithms based on manual identification of electrocardiogram (ECG) features, have been developed. However, the reported accuracy decreases when tested with different datasets. Machine learning algorithms can automatize the process and improve generalization, but their performance is hampered by the lack of large enough OTVA databases. We propose the use of detailed electrophysiological simulations of OTVAs to train a machine learning classification model to predict the ventricular origin of the SOO of ectopic beats. We generated a synthetic database of 12-l…