0000000000956240

AUTHOR

Abdiel Quintero

showing 2 related works from this author

Ex vivo T-cell depletion vs post-transplant cyclophosphamide, sirolimus, and mycophenolate mofetil as graft-vs-host disease prophylaxis for allogenei…

2021

Objective To compare the efficacy and safety of CD34+ selected ex vivo T-cell depletion (TCD) vs post-transplant cyclophosphamide, sirolimus, and mycophenolate mofetil (PTCy-Sir-MMF) as graft-vs-host disease (GVHD) prophylaxis. Methods We retrospectively included patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) with either TCD (n = 38) or PTCy-Sir-MMF (n = 91). Results Cumulative incidence of neutrophil and platelet recovery was 92% vs 99% (P = .06) and 89% vs 97% (P = .3) in TCD and PTCy-Sir-MMF, respectively. Cumulative incidences of aGHVD grade II-IV, III-IV, and moderate to severe cGVHD were 11% vs 19% (P = .2), 3% vs 2% (P = .9), and 3% vs 36% (P < …

Malemedicine.medical_treatmentT-LymphocytesCD34Graft vs Host DiseaseHematopoietic stem cell transplantationMycophenolateGastroenterologySeverity of Illness IndexLeukocyte Count0302 clinical medicineImmune ReconstitutionPostoperative ComplicationsRecurrenceGVHD prophylaxisAntineoplastic Combined Chemotherapy ProtocolsCumulative incidenceHematopoietic Stem Cell TransplantationT-cell depletionHematologyGeneral MedicineMiddle AgedPrognosisLeukemia Myeloid Acutesurgical procedures operativeTreatment OutcomeT-cell depletion030220 oncology & carcinogenesishematopoietic stem cell transplantationcardiovascular systemFemalemedicine.drugAdultmedicine.medical_specialtyCyclophosphamideAdolescentLymphocyte Depletion03 medical and health sciencesYoung AdultInternal medicinemedicineHumansTransplantation HomologousGVHD prophylaxis T-cell depletion hematopoietic stem cell transplantation post-transplantation cyclophosphamideCyclophosphamideAgedPostoperative CareSirolimuspost-transplantation cyclophosphamidebusiness.industryMycophenolic AcidSirolimusbusinessEx vivoBiomarkers030215 immunologyEuropean journal of haematologyREFERENCES
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Sirolimus versus cyclosporine in haploidentical stem cell transplantation with posttransplant cyclophosphamide and mycophenolate mofetil as graft‐ver…

2021

Sirolimus has emerged as an alternative to calcineurin inhibitors-based (CNI) graft-versus-host disease (GVHD) prophylaxis. This retrospective study compares the outcome of 133 consecutive adult patients with haematological malignancies undergoing haploidentical stem cell transplantation with posttransplant cyclophosphamide (PTCy) and mycophenolate mofetil (MMF), combined with cyclosporine A (PTCy-CsA-MMF,

medicine.medical_specialtyHaploidentical transplantationCyclophosphamidebusiness.industryUrologyMycophenolatemedicine.diseaseTransplantationGraft-versus-host diseaseSirolimusToxicityMedicineStem cellbusinessmedicine.drugeJHaem
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