0000000000957292
AUTHOR
R. Palumbo
Efficacy and safety of Everolimus and Exemestane in hormone-receptor positive (HR+) human-epidermal-growth-factor negative (HER2−) advanced breast cancer patients: New insights beyond clinical trials. The EVA study
Abstract Background The BOLERO-2 trial reported efficacy and safety of Everolimus (EVE) and Exemestane (EXE) combination in HR+ advanced breast cancer (ABC) patients. The BALLET trial further evaluated the safety of EVE-EXE in HR+ ABC patients, without reporting efficacy data. Aim of the EVA real-life study was to collect data of efficacy and safety of EVE-EXE combination in the clinical setting, as well as exploring efficacy according to EVE Dose-Intensity (DI) and to previous treatment with Fulvestrant. Patients and methods This study aimed to describe the outcome of ABC pts treated with EVE-EXE combination in terms of median duration of EVE treatment and ORR in a real-life setting. Resul…
Female age at first pregnancy and work task: finding correlation and evolution over the past two decades in a Sicilian province
Background: the entrance of women in the workforce, due to a their growing cultural and, accordingly, social commitment, changed many aspects of their lives; the research or the maintenance of a job, especially during periods of severe economic crisis, leads to a delay of many physiological stage, maternity at first. The aim of this study is to verify and, if it really happened, to quantify an increasing age of first-time mothers in a sample of mothers in the province of Agrigento in the last 20 years, correlating any positive response to the work task performed. Material and Methods: we have enrolled all primiparous women who gave birth in a hospital in the province of Agrigento, from Janu…
Everolimus (EVE) and exemestane (EXE) in patients with advanced breast cancer aged ≥ 65 years: New lessons for clinical practice from the EVA study
BACKGROUND: The present analysis focuses on real-world data of Everolimus- Exemestane in advanced HR+ve, HER2-ve elderly breast cancer patients (aged 65 years) included in the EVA study, with unique findings in those aged 70 years. METHODS: Data are collected from clinical records and analysed according to age cut-off (< 65 years; 65 - 69 years and [greater than or equal to] 70 years). Relationship of analyzed variables with response were tested by mean of a Mantel- Haenszel chi square test. Time to event analysis was described by Kaplan Meier approach and association with baseline characteristics was analysed by stratified log-rank test and proportional hazard model. RESULTS: From July …
Mycotoxin mixtures in food and feed: a holistic, innovative, flexible modelling approach for risk assessment MYCHIF
Mycotoxin contamination can occur in many agricultural products both destined to food and feed. Mycotoxins are produced as the result of fungal metabolism and plant-pathogen interaction. Therefore, many structurally-related congeners, defined as modified mycotoxins are generated by plant &/or fungi metabolism, or food processing, and coexist with their native forms. Studies investigating the co-occurrence of multiple-mycotoxins reported 75%100% of samples containing more than one mycotoxin, referring to native compounds and 100% reported multiple modified forms. A major challenge in a risk assessment is to depict the biosynthesis of mycotoxin mixtures and their realistic occurrence. Over th…