0000000000959304
AUTHOR
A. Roth
Radioimmunological determination of somatomedin B in healthy children and patients with HGH deficiency
In 192 boys and girls, aging from 1 month to 16 years, serum somatomedin B levels were performed by radioimmunoassay of Kabi Inc., slightly modified. In girls the mean value increased from the 1 st. month at the end of the second year of live from 10.5±6.2 to 19.2±9.2 mg/1, in boys at the same time from 10±3.9 to 20.3±6.2 mg/1. The values decreased in girls in the following years up to the age of 14-16 years to 13.7±7.5 mg/1; in the boys to 11.5±4.2mg/1. The beginning of the decrease was in girls two years earlier than in boys. To these values of normal children were compared the values of 8 patients with HGH deficiency. The mean of these cildren was 4.2 mg/1, significantly below the values…
Aerosol properties, source identification, and cloud processing in orographic clouds measured by single particle mass spectrometry on a central European mountain site during HCCT-2010
Cloud residues and out-of-cloud aerosol particles with diameters between 150 and 900 nm were analysed by online single particle aerosol mass spectrometry during the 6-week study Hill Cap Cloud Thuringia (HCCT)-2010 in September–October 2010. The measurement location was the mountain Schmücke (937 m a.s.l.) in central Germany. More than 160 000 bipolar mass spectra from out-of-cloud aerosol particles and more than 13 000 bipolar mass spectra from cloud residual particles were obtained and were classified using a fuzzy c-means clustering algorithm. Analysis of the uncertainty of the sorting algorithm was conducted on a subset of the data by comparing the clustering output with particle-by-par…
Search for neutral Higgs bosons from supersymmetry in Z decays
The light scalar Higgs boson h and the pseudoscalar Higgs boson A of the minimal supersymmetric standard model have been searched for in the processes e+e−→hff and e+e−→hA using data collected by ALEPH at the LEP e+e− collider, with center of mass energies at and near the Z peak. Using a variety of signatures adapted to various mass ranges for h and A, we have excluded a large domain in the parameter space. For large values of ν2ν1, the ratio of the vacuum expectation values of the two Higgs fields, the whole range from 0 to 38.8 GeV is excluded for Mh and MA at 95% CL.
Searches for the standard Higgs boson
Abstract A data sample corresponding to about 100 000 hadronic Z decays collected by ALEPH at LEP has been used to search for the standard Higgs boson produced in the reaction e + e − → H 0 Z 0∗ . No indication for any signal was found, and a 95% CL lower limit on the Higgs boson mass has been set at 41.6 GeV.
Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1
Abstract Richter’s transformation (RT) is an aggressive lymphoma that occurs upon progression from chronic lymphocytic leukemia (CLL). Transformation has been associated with genetic aberrations in the CLL phase involving TP53, CDKN2A, MYC, and NOTCH1; however, a significant proportion of RT cases lack CLL phase–associated events. Here, we report that high levels of AKT phosphorylation occur both in high-risk CLL patients harboring TP53 and NOTCH1 mutations as well as in patients with RT. Genetic overactivation of Akt in the murine Eµ-TCL1 CLL mouse model resulted in CLL transformation to RT with significantly reduced survival and an aggressive lymphoma phenotype. In the absence of recurren…
Measurement of Prompt Photon Production In Hadronic-z Decays
The production of isolated photons in hadronic Z decays is measured with the ALEPH detector at LEP using a sample of 450 000 hadronic events. The corrected rate is given for several values of the minimum invariant mass squared cut between the photon and the jets. This measurement of final state radiation from the quarks is compared with the predictions of parton shower models JETSET, ARIADNE and HERWIG as well as with the predictions of QCD matrix element calculations. RI Perrier, Frederic/A-5953-2011; ANTONELLI, ANTONELLA/C-6238-2011; Buttar, Craig/D-3706-2011; Stahl, Achim/E-8846-2011; Passalacqua, Luca/F-5127-2011; Murtas, Fabrizio/B-5729-2012; St.Denis, Richard/C-8997-2012; Forti, Franc…
Search for a new weakly interacting particle
Abstract A search for events of the type e + e − →l + l − X 0 , where X 0 can be any weakly interacting particle which couples to the Z, has been performed with the ALEPH detector at LEP, by searching for acollinear lepton pairs. Such particles can be excluded up to a mass of 7.0 GeV/c 2 for a value of the ratio of branching fractions, Br( Z →X 0 l + l − )/Br(Z→ l + l − ), greater than 2.5 × 10 −3 if the X 0 has third component of isospin, I 3 greater than 1 2 and decays to a pair of virtual gauge bosons. When this analysis is combined with the previous results of the Higgs particle searches from ALEPH, this limit can be extended to an X 0 mass of 60 GeV/c 2 .
Search for excited leptons in Z0 decay
Due to the severity of system-wide power outages, though their probability of occurrence is slight, regulatory authorities require that a system restoration plan be drawn up and kept up to date at all times. The power outage that affected northeastern North America in 2003 proved the need for such a requirement. The particular structure of Hydro-Quebec's power system requires the use of a highly specific system restoration procedure. The daily preparation of the system restoration plan is based on a strategy whose application requires that a restoration sequence be drawn up that uses available equipment, the electrical behavior of which has been validated using appropriate studies. Over the…
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…
Search for supersymmetric particles using acoplanar charged-particle pairs from Z0 decays
We have performed a search for supersymmetric particles using acoplanar pairs of oppositely-charged particles in decays of the Z0. In 0.53 pb−1 of integrated luminosity near the Z0 peak, we observe two events where approximately four are expected from background, allowing limits to be extended on combined photino and slepton masses, and also on combined photino and chargino masses.
Lifetime of the metastable 6P 3/2 level of PbII
Pb+-ions were stored in a r.f.-quadrupole trap. Short laser pulses at a 710-nm M1-transition excited the ions to the metastable 6P 3/2 level. Time-resolved registration of the subsequent decay photons at the same wavelength directly gives the lifetime of that state. No dependence of the decay rate on the density of different buffer gases up to 10−5 mbar pressure was observed and from this we deduced upper limits to the quenching cross section. We have observed, however, a small dependence on the stored ion number. The final result for the lifetime is 41.2 ± 0.7 ms in agreement with the result of a previous calculation.
TRACKING WITH THE ALEPH TIME PROJECTION CHAMBER
The tracking performance of the ALEPH time projection chamber (TPC) has been studied using the data taken during the LEP (Large Electron-Positron Collider) running periods in 1989 and 1990. After careful correction of residual distortions and optimization of coordinate reconstruction algorithms, a single coordinate resolution of 173 mu m in the azimuthal and 740 mu m in the longitudinal direction is achieved. This results in a momentum resolution for the TPC alone of Delta p/p/sup 2/=0.0012 (GeV/c)/sup -1/. In combination with the ALEPH inner tracking chamber (ITC), a total momentum resolution of Delta p/p/sup 2/=0.0008 (GeV/c)/sup -1/, close to the design specifications, is reached. >
Search for decays of the Z0 into a photon and a pseudoscalar meson
Abstract A search is reported for decays of the Z 0 into π 0 γ , ηγ and η ′ (958) γ in e + e − collisions using data collected during a scan around the Z 0 mass. In order to search for π 0 γ final states, in which the two photons from the π 0 decay are unresolved, the production of pairs of high-energy electromagnetic clusters is studied. The data are compared with the expectations from the pure QED process e + e − → γγ , and a 95% confidence level upper limit on the branching ratio of the Z 0 into π 0 γ of 4.9 × 10 −4 is derived. For η′γ, the decay modes of the mesons that contain two charged particles are largely free from QED background. These modes are used to place upper limits of 4.6 …
The diagnosis and management of gastric cancer: Expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010
Well-recognized experts in the field of gastric cancer discussed during the 12th European Society Medical Oncology (ESMO)/World Congress Gastrointestinal Cancer (WCGIC) in Barcelona many important and controversial topics on the diagnosis and management of patients with gastric cancer. This article summarizes the recommendations and expert opinion on gastric cancer. It discusses and reflects on the regional differences in the incidence and care of gastric cancer, the definition of gastro-esophageal junction and its implication for treatment strategies and presents the latest recommendations in the staging and treatment of primary and metastatic gastric cancer. Recognition is given to the ne…
Measurement of the ground state hyperfine splitting in207Pb II
The ground state hyperfine splitting of simply ionized lead has been determined using pulsed laser excitation of electrodynamically confined ions. We obtain ΔV(6P1/2)=12.85(10) GHz
Search for excited neutrinos in Z decay
Excited neutrinos decaying into a neutrino and a photon are searched for in the ALEPH detector at LEP. No evidence is found for Z decay into vv∗ or v∗v∗ final states. Upper limits are derived on excited neutrino couplings up to excited neutrino masses close to the Z mass. Lower limits on the v∗ mass, independent of the v∗ decay modes, are deduced from the total Z width.
The read-out processors of the Aleph time projection chamber and their performance
The Aleph detector is installed on the LEP electron-positron storage ring. Its central tracking detector, a time projection chamber (TPC), has about 50000 channels of sampling electronics. The digitized signals are processed by 72 double-width Fastbus modules built around an MC 68020 processor. The time projection processor is described, and the solutions, both hardware and software, adopted to run and manage such a complex system in a Fastbus-VAX environment are discussed. Practical experience with the system is reported. >
EURECCA colorectal: multidisciplinary mission statement on better care for patients with colon and rectal cancer in Europe
Contains fulltext : 125368.pdf (Publisher’s version ) (Closed access) BACKGROUND: Care for patients with colon and rectal cancer has improved in the last twenty years however still considerable variation exists in cancer management and outcome between European countries. Therefore, EURECCA, which is the acronym of European Registration of cancer care, is aiming at defining core treatment strategies and developing a European audit structure in order to improve the quality of care for all patients with colon and rectal cancer. In December 2012 the first multidisciplinary consensus conference about colon and rectum was held looking for multidisciplinary consensus. The expert panel consisted of…
Production and decay of charmed mesons at the Z resonance
Abstract In a sample of 190 000 hadronic Z decays, three signals of charm production are observed: two from the exclusive decays D ° → K − π + and D ∗+ → D °π + → K − π + π + and one in the transverse-momentum distribution of soft hadrons relative to the nearest jet. The features of these signals are in good agreement with expectations based on the standard model and previous measurements of the branching fractions. The number of D ∗± → K ± π ± π ± per hadronic decay of the Z is measured to be (5.11±0.34) × 10 −3 , and the branching ratio B(D 0 → K − π + ) is (3.62 ± 0.34 ± 0.44)%. Charm hadronization has been studied. The average fraction of the beam energy carried by the D ∗ meson is foun…
Aerosol properties, source identification, and cloud processing in orographic clouds measured by single particle mass spectrometry on a Central European mountain site during HCCT-2010
Abstract. Cloud residues and out-of-cloud aerosol particles with diameters between 150 and 900 nm have been analysed by on-line single particle aerosol mass spectrometry during the six-week study HCCT-2010 in September/October 2010. The measurement location was the mountain Schmücke (937 m a.s.l.) in Central Germany. More than 170 000 bipolar mass spectra from out-of-cloud aerosol particles and more than 14 000 bipolar mass spectra from cloud residual particles were obtained and were classified using a fuzzy c-means clustering algorithm. Analysis of the uncertainty of the sorting algorithm was conducted on a subset of the data by comparing the clustering output with particle-by-particle ins…
PERFORMANCE OF THE ALEPH TIME PROJECTION CHAMBER
The performance of the ALEPH Time Projection Chamber (TPC) has been studied using data taken during the LEP running periods in 1989 and 1990. After correction of residual distortions and optimisation of coordinate reconstruction algorithms, single coordinate resolutions of 173-mu-m in the azimuthal and 740-mu-m in the longitudinal direction are achieved. This results in a momentum resolution for the TPC of DELTA-p/p2 = 1.2 x 10(-3) (GeV/c)-1. In combination with the ALEPH Inner Tracking Chamber (ITC), a total momentum resolution of DELTA-p/p2 = 0.8 x 10(-3) (GeV/c)-1 is obtained. With respect to particle identification, the detector achieves a resolution of 4.4% for the measurement of the i…
Measurement of the B hadron lifetime
The average lifetime of B hadrons has been measured by the ALEPH experiment at LEP. Events containing B hadrons are selected by the identification of leptons with high transverse momentum in hadronic Z decays, and the lifetime is extracted from a fit to the impact parameter distribution of the lepton tracks. From a sample of 1.7×105 hadronic Z decays a lifetime of 1.29±0.06±0.10 ps is measured.
Measurement of B- mixing at the Z
Abstract From more than 175 000 hadronic Z decays observed with the ALEPH detector at LEP, we select 823 events with pairs of leptons in the final state. From these we measure χ , the probability thata b hadron which is observed to decay originated as a b hadron. We find χ =0.132 −0.026 +0.027 .
Measurement of the strong coupling constant alfa_s from global event-shape variables of hadronic Z decays
Abstract An analysis of global event-shape variables has been carried out for the reaction e+e−→Z0→hadrons to measure the strong coupling constant αs. This study is based on 52 720 hadronic events obtained in 1989/90 with the ALEPH detector at the LEP collider at energies near the peak of the Z-resonance. In order to determine αs, second order QCD predictions modified by effects of perturbative higher orders and hadronization were fitted to the experimental distributions of event-shape variables. From a detailed analysis of the theoretical uncertainties we find that this approach is best justified for the differential two-jet rate, from which we obtain αs(MZ2) = 0.121 ± 0.002(stat.)±0.003(s…
Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - differential treatment strategies for subtypes of early gastroesophageal cancer.
The 1st St. Gallen EORTC Gastrointestinal Cancer Conference 2012 Expert Panel clearly differentiated treatment and staging recommendations for the various gastroesophageal cancers. For locally advanced gastric cancer (>= PT3N+), the preferred treatment modality was pre- and postoperative chemotherapy. The majority of panel members would also treat T2N+ or even T2N0 tumours with a similar approach mainly because pretherapeutic staging was considered highly unreliable. It was agreed that adenocarcinoma of the gastroesophageal junction (AEG) is classified best according to Siewert et al. Preoperative radiochemotherapy (RCT) is the preferred treatment for AEG type I and II tumours. For AEG type…