0000000000959339

AUTHOR

Bart Deplancke

showing 2 related works from this author

Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA…

2020

Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatiotemporal patterns of genetic variation in natural populations have been challenging, as comprehensive sampling is logistically difficult, and sequencing of entire populations costly. Here, we address these issues using a collaborative approach, sequencing 48 pooled population samples from 32 locations, and perform the first continent-wide genomic analysis of genetic variation in European Drosophila melanogaster. Our analyses uncover longitudinal population structure, provide evidence for continent-wide selective sweeps, ide…

0106 biological sciencesMaleincipient sexual isolationQH301 BiologyAcclimatizationADNGenome Insect01 natural sciencesPopulation genomicsAdaptation; Clines; Demography; Population genomics; Selection; SNPs; Structural variants; Acclimatization; Altitude; Animals; DNA Viruses; Drosophila melanogaster; Europe; Genome Mitochondrial; Haplotypes; Insect Viruses; Male; Phylogeography; Polymorphism Single Nucleotide; Genome Insect; Genomic Structural Variation; Microbiota; Selection GeneticSDG 13 - Climate ActionComputingMilieux_MISCELLANEOUSeducation.field_of_study0303 health sciencesAltitude[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]PE&RCgeneettinen muunteluPhylogeographyDrosophila melanogasterLaboratory of GeneticsTransposable elementnorth-americanmahlakärpäsetSettore BIO/18 - GENETICAselectionLaboratorium voor Erfelijkheidsleeramino-acid polymorphism03 medical and health sciencesGeneticGeneticsAdaptation demographyMicrobiomeAdaptationPolymorphismeducationDrosophilaMolecular BiologySelectionEcology Evolution Behavior and SystematicsDemography[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]DNAchemistryEvolutionary biologyGenome MitochondrialGenomic Structural Variationinversion in(3r)payneAdaptationPopulation genomicsStructural variantsGenètica[SDV.EE.IEO]Life Sciences [q-bio]/Ecology environment/Symbiosisadaptation demographyCandidate genenucleotide polymorphismAcademicSubjects/SCI01180chemistry.chemical_compoundMelanogaster2. Zero hungerGenomebiologyMicrobiotaSingle NucleotideClinesclinesMitochondrialEuropepopulaatiogenetiikkatransposable elementsDrosophila melanogasterSNPsnatural-populationspopulation genomicsPopulationnext-generationDrosòfila melanogasterInsect Viruses010603 evolutionary biologyPolymorphism Single NucleotideQH301latitudinal clineGenetic variationAnimalsSelection GeneticSelection (genetic algorithm)DiscoveriesLocal adaptation030304 developmental biologylife-historyAcademicSubjects/SCI01130DNA Virusesstructural variantsDASbiology.organism_classificationHaplotypes13. Climate actionperimä[SDE.BE]Environmental Sciences/Biodiversity and EcologyInsectDNAMolecular Biology and Evolution
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cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel

2020

Abstract Background Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understanding of how the effects of genetic variants affect different molecular mechanisms to determine gut immunocompetence is still limited. Results To address this, we perform a systems genetics analysis of the gut transcriptomes from 38 DGRP lines that were orally infected with Pseudomonas entomophila. We identify a large number of condition-specific, expression quantitative trait loci (local-eQTLs) with infection-specific ones located …

lcsh:QH426-470Quantitative Trait Locimotifsallele-specific expressionPolymorphism Single Nucleotidecomplex traitsgenerationPseudomonasAnimalsDrosophila ProteinsRegulatory Elements Transcriptionallcsh:QH301-705.5AllelesBinding SitesResearchF-Box ProteinsassociationForkhead Transcription FactorsGastrointestinal Tractlcsh:GeneticsDrosophila melanogasterlcsh:Biology (General)dissectionresponsesFemaleTranscriptomerevealsdiscoveryGenome Biology
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