6533b854fe1ef96bd12ae91c
RESEARCH PRODUCT
Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses
Banu Sebnem OnderElena G. PasyukovaMontserrat AguadéEva PuermaAnnabelle HaudryMaite G. BarrónJorge VieiraJorge VieiraMartin KapunDamiano PorcelliLain GuioJohn ParschMaria Pilar Garcia GuerreiroBas J. ZwaanIryna KozeretskaIryna KozeretskaOmar Rota-stabelliFabian StaubachMaría Bogaerts-márquezMichael G. RitchiePaul SchmidtThomas FlattThomas FlattCristina VieiraBart DeplanckeJessica K. AbbottSvitlana SergaJosefa GonzálezMarta PascualSonja GrathLena WaideleDorcas J. OrengoPatricia GibertNico PosnienDarren J. ObbardCristina P. VieiraCristina P. VieiraCatherine Montchamp-moreauMads Fristrup SchouMads Fristrup SchouEran TauberAlejandro Sánchez-graciaClément GoubertClément GoubertAndrea J. BetancourtAlan O. BerglandEliza ArgyridouMaaria KankareÉLio SucenaÉLio SucenaR. Axel W. WibergR. Axel W. WibergVolker Loeschckesubject
0106 biological sciencesMaleincipient sexual isolationQH301 BiologyAcclimatizationADNGenome Insect01 natural sciencesPopulation genomicsAdaptation; Clines; Demography; Population genomics; Selection; SNPs; Structural variants; Acclimatization; Altitude; Animals; DNA Viruses; Drosophila melanogaster; Europe; Genome Mitochondrial; Haplotypes; Insect Viruses; Male; Phylogeography; Polymorphism Single Nucleotide; Genome Insect; Genomic Structural Variation; Microbiota; Selection GeneticSDG 13 - Climate ActionComputingMilieux_MISCELLANEOUSeducation.field_of_study0303 health sciencesAltitude[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]PE&RCgeneettinen muunteluPhylogeographyDrosophila melanogasterLaboratory of GeneticsTransposable elementnorth-americanmahlakärpäsetSettore BIO/18 - GENETICAselectionLaboratorium voor Erfelijkheidsleeramino-acid polymorphism03 medical and health sciencesGeneticGeneticsAdaptation demographyMicrobiomeAdaptationPolymorphismeducationDrosophilaMolecular BiologySelectionEcology Evolution Behavior and SystematicsDemography[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]DNAchemistryEvolutionary biologyGenome MitochondrialGenomic Structural Variationinversion in(3r)payneAdaptationPopulation genomicsStructural variantsGenètica[SDV.EE.IEO]Life Sciences [q-bio]/Ecology environment/Symbiosisadaptation demographyCandidate genenucleotide polymorphismAcademicSubjects/SCI01180chemistry.chemical_compoundMelanogaster2. Zero hungerGenomebiologyMicrobiotaSingle NucleotideClinesclinesMitochondrialEuropepopulaatiogenetiikkatransposable elementsDrosophila melanogasterSNPsnatural-populationspopulation genomicsPopulationnext-generationDrosòfila melanogasterInsect Viruses010603 evolutionary biologyPolymorphism Single NucleotideQH301latitudinal clineGenetic variationAnimalsSelection GeneticSelection (genetic algorithm)DiscoveriesLocal adaptation030304 developmental biologylife-historyAcademicSubjects/SCI01130DNA Virusesstructural variantsDASbiology.organism_classificationHaplotypes13. Climate actionperimä[SDE.BE]Environmental Sciences/Biodiversity and EcologyInsectDNAdescription
Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatiotemporal patterns of genetic variation in natural populations have been challenging, as comprehensive sampling is logistically difficult, and sequencing of entire populations costly. Here, we address these issues using a collaborative approach, sequencing 48 pooled population samples from 32 locations, and perform the first continent-wide genomic analysis of genetic variation in European Drosophila melanogaster. Our analyses uncover longitudinal population structure, provide evidence for continent-wide selective sweeps, identify candidate genes for local climate adaptation, and document clines in chromosomal inversion and transposable element frequencies. We also characterize variation among populations in the composition of the fly microbiome, and identify five new DNA viruses in our samples.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-01 | Molecular Biology and Evolution |