0000000000960908
AUTHOR
M. Garcia
Four colour photometry of late-type binary systems
This paper presents rst complete uvby light curves of the late-type detached eclipsing binary ZZ UMa (G0V + G8V, P =2 : d 2993). This binary system has been observed during eight campaigns at the Calar Alto Observatory (Almeria, Spain)and at the Sierra Nevada Observatory (Granada, Spain). 294 points distributed over the binary period and covering both eclipses are given. The comparison stars used to calculate the dierential light curves (SAO 15242 and SAO 15251) were conrmed as being good reference stars with constant flux. These observations are part of a 6 year uvby and H monitor- ing program of low mass eclipsing binaries whose main objective is to provide accurate absolute astrophysical…
The NHXM observatory
Exploration of the X-ray sky has established X-ray astronomy as a fundamental astrophysical discipline. While our knowledge of the sky below 10 keV has increased dramatically (∼8 orders of magnitude) by use of grazing incidence optics, we still await a similar improvement above 10 keV, where to date only collimated instruments have been used. Also ripe for exploration is the field of X-ray polarimetry, an unused fundamental tool to understand the physics and morphology of X-ray sources. Here we present a novel mission, the New Hard X-ray Mission (NHXM) that brings together for the first time simultaneous high-sensitivity, hard-X-ray imaging, broadband spectroscopy and polarimetry. NHXM will…
Four colour photometry of late-type binary systems
This paper presents new complete uvby light curves of the late-type detached eclipsing binary BH Vir (G0V + G5V, P =0 : 81687099). This binary system has been observed during four cam- paigns at the Calar Alto Observatory (Almeria, Spain) and at the European Southern Observatory (La Silla, Chile). This observations are part of a 6 yearuvby and H monitoring program of low mass eclipsing binaries which main objective is to provide accurate absolute astrophys- ical parameters for late-type main sequence stars. 1585 points spreaded over the binary period and covering both eclipses are given. The internal accuracy of the standard photometry measured as the mean RMS of the dierences between stand…
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…
The estrogen receptor α:insulin receptor substrate 1 complex in breast cancer: structure–function relationships
Background: Insulin receptor substrate 1 (IRS-1) is a signaling molecule that exerts a key role in mediating cross talk between estrogen receptor a (ERa) and insulin-like growth factor 1 (IGF-1) in breast cancer cells. Previously, we demonstrated that a fraction of IRS-1 binds ERa, translocates to the nucleus, and modulates ERa-dependent transcription at estrogen response elements (ERE). Here, we studied structure-function relationships of the ER-a:IRS-1 complex under IGF-1 and/or estradiol (E 2 ) stimulation. Materials and methods: ERa and IRS-1 deletion mutants were used to analyze structural and functional ERα/IRS-1 interactions. IRS-1 binding to ERE and IRS-1 role in ERa-dependent ERE t…
Searches for violation of lepton flavour and baryon number in tau lepton decays at LHCb
Searches for the lepton flavour violating decay tau(-) -> mu(-)mu(+)mu(-) and the lepton flavour and baryon number violating decays tau(-) -> (p) over bar mu(+)mu(-) and tau(-) -> p mu(-)mu(-) have been carried out using proton-proton collision data, corresponding to an integrated luminosity of 1.0 fb(-1), taken by the LHCb experiment at root s = 7 TeV. No evidence has been found for any signal, and limits have been set at 90% confidence level on the branching fractions: B(tau(-) -> mu(-)mu(+)mu(-) mu(+)mu(-)) p mu(-)mu(-)) (p) over bar mu(+)mu(-) and tau(-) -> p mu(-)mu(-) decay modes represent the first direct experimental limits on these channels.
Impact of sex, age, and risk factors for venous thromboembolism on the initial presentation of first isolated symptomatic acute deep vein thrombosis
Abstract Background and aims Sex-specific differences exist for the initial presentation of acute venous thromboembolism (VTE): men are more likely to present with proximal deep vein thrombosis (DVT) in the lower limbs (versus pulmonary embolism [PE] or isolated distal DVT [IDDVT]) than women. We studied in detail the influence of sex, age, and VTE risk factors on the initial presentation of IDDVT versus proximal DVT. Methods A total of 24,911 patients with a first episode of objectively diagnosed acute symptomatic lower-limb DVT (without symptomatic PE) were enrolled in RIETE (years 2000–2017) and included in the present analysis. Results A total of 4266 (17.1%) patients had IDDVT. No tren…
Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score
The British journal of surgery 108(11), 1274-1292 (2021). doi:10.1093/bjs/znab183
Absolute parameters for binary systems
New high-quality light curves of the late-type binary system BH Vir have been obtained during a 6 year photometric uvby and monitoring program of low mass eclipsing binaries (Clement et al. 1997), hereafter Papers I and II. This paper presents detailed analysis of this binary based on the four light curves obtained within our program. The activity wave superimposed on the eclipse-modulated light curves has been adjusted and removed by using a new iterative application of the standard EBOP code together with truncated Fourier Series fittings. Combining the recent radial velocity curves (Popper 1995) with the geometrical elements deduced from the "clean" photometric light curves, the absolute…
Absolute parameters for binary systems
New light curves of the late-type binary sys- tem ZZ UMa were obtained during a uvby and H mon- itoring program on low mass eclipsing binaries, that has been carried out in a six year photometric observational program (Clement et al. 1997a, Paper I). The main goal of the program is to obtain accurate absolute parameters for stars in the low and intermediate mass range, in order to improve the Mass-Luminosity Relationship (MLR) at the end of the main sequence. This paper presents a complete analysis of the rst uvby light curves of the late-type detached eclipsing binary ZZ UMa. This binary system has been observed during eight campaigns at the Calar Alto Observatory (Almeria, Spain). The act…
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locu…