The synergistic effect exerted by the HDAC inhibitor SAHA and the sesquiterpene lactone parthenolide on triple negative breast canc er cells

Triple-negative breast cancer (TNBC) is a subtype o f breast cancer, insensitive to endocrine therapy. Chemotherapy is the main form of treatment, but is accompanied by a high rate of recidivism. The sesquiterpene lactone Parthenolide (PN) exerts a cy totoxic effect on MDA-MB231 cells, a TNBC cell line (1), but was ineffective at low doses (2-5μM). This repr esents an obstacle for a therapeutic utilization of PN. We supposed, in line with other authors (2), that PN c auses a protective response, which at low doses pre vails on the cytotoxic effect. With the aim of inhibiting this protective effect we have shown that pre-trea tment of MDA-MB231 cells with SAHA (2-5μM), an histone deace tylat…

Mapping of activation frequencies during ventricular fibrillation in isolated perfused healthy human heart

The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study

Abstract Background It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time–weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events. Methods Posthoc retrospective propensity score–weighted cohort analysis of patients undergoing open or closed abdominal surgery in the ‘Local ASsessment of Ventilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries.…

Intraoperative transfusion practices in Europe

PubMed: 26787795

Lightest Higgs boson production at photon colliders in the two Higgs doublet model type III

The branching ratios of the lightest $CP$-even Higgs boson ${h}^{0}$ are calculated in the framework of the general two higgs doublet model. Different scenarios are presented taking into account constraints on the flavor changing neutral currents factors obtained in previous works. Plausible scenarios where appear flavor changing processes at tree level like $b\overline{s}$ and $t\overline{c}$ are analyzed for relevant parameters. The loop-induced Higgs couplings to photon pairs can be tested with a photon collider. The number of events of ${h}^{0}$ as a resonance in photon colliders are calculated taking into account its corresponding background signal at TESLA, CLIC, and NLC.