0000000000965170

AUTHOR

On Behalf Of Kiriind (Kir Infectious And Inflammatory Diseases) Collaborative Group

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HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute ischemic stroke

2019

Abstract Introduction In humans, a major component of natural killer (NK) and T cell target recognition depends on the surveillance of human leukocyte antigen (HLA) class I molecules by killer immunoglobulin-like receptors (KIRs). Aims To implement the knowledge about the immunological genetic background of acute ischemic stroke susceptibility in relation to the frequency of the KIR genes and HLA alleles. Methods Subjects with acute ischemic stroke and subjects without stroke were genotyped for the presence of KIR genes and of the three major KIR ligand groups, HLA-C1, HLA-C2, and HLA-Bw4, both HLA-B and HLA-A loci. Results Between November 2013 and February 2016, consecutive patients with …

MaleKiller immunoglobulin-like receptors (KIRs)0301 basic medicinemedicine.medical_specialtySettore MED/09 - Medicina InternaNeurologyGenotypeT cellKIR LigandImmunologyKiller-cell immunoglobulin-like receptorchemical and pharmacologic phenomenaHuman leukocyte antigenlcsh:RC346-429Proinflammatory cytokine03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineReceptors KIRotorhinolaryngologic diseasesHumansMedicineGenetic Predisposition to DiseaseReceptorStrokelcsh:Neurology. Diseases of the nervous systemAgedSettore MED/04 - Patologia GeneraleNeuroscience (all)business.industryResearchGeneral NeuroscienceHistocompatibility Antigens Class IMiddle Agedmedicine.diseaseStrokeHLACross-Sectional Studies030104 developmental biologymedicine.anatomical_structureNeurologyImmunologyFemalebusiness030217 neurology & neurosurgeryJournal of Neuroinflammation
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