0000000000967906

AUTHOR

Peter Jedlicka

showing 2 related works from this author

Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons.

2021

The impact of GABAergic transmission on neuronal excitability depends on the Cl--gradient across membranes. However, the Cl--fluxes through GABAA receptors alter the intracellular Cl- concentration ([Cl-]i) and in turn attenuate GABAergic responses, a process termed ionic plasticity. Recently it has been shown that coincident glutamatergic inputs significantly affect ionic plasticity. Yet how the [Cl-]i changes depend on the properties of glutamatergic inputs and their spatiotemporal relation to GABAergic stimuli is unknown. To investigate this issue, we used compartmental biophysical models of Cl- dynamics simulating either a simple ball-and-stick topology or a reconstructed CA3 neuron. Th…

Databases FactualPhysiologyNervous SystemBiochemistrySynaptic TransmissionAnimal CellsMedicine and Health SciencesCl effluxBiology (General)Receptorgamma-Aminobutyric AcidNeuronsNeuronal PlasticityEcologyNeuronal MorphologyGABAA receptorChemistryPyramidal CellsNeurochemistryNeurotransmittersCA3 Region HippocampalElectrophysiologymedicine.anatomical_structureComputational Theory and MathematicsModeling and SimulationGABAergicAnatomyCellular TypesReceptor PhysiologyIntracellularResearch ArticleCell PhysiologyQH301-705.5Models NeurologicalNeurophysiologyMembrane PotentialCellular and Molecular NeuroscienceGlutamatergicChloridesGeneticsmedicineAnimalsMolecular BiologyEcology Evolution Behavior and SystematicsBiology and Life SciencesComputational BiologyCell BiologyNeuronal DendritesReceptors GABA-ACellular NeuroscienceSynapsesCa3 pyramidal neuronDepolarizationNeuronNeuroscienceNeurosciencePLoS Computational Biology
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Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons

2020

AbstractThe impact of GABAergic transmission on neuronal excitability depends on the Cl−-gradient across membranes. However, the Cl−-fluxes through GABAA receptors alter the intracellular Cl− concentration ([Cl−]i) and in turn attenuate GABAergic responses, a process termed ionic plasticity. Recently it has been shown that coincident glutamatergic inputs significantly affect ionic plasticity. Yet how the [Cl−]i changes depend on the properties of glutamatergic inputs and their spatiotemporal relation to GABAergic stimuli is unknown. To investigate this issue, we used compartmental biophysical models of Cl− dynamics simulating either a simple ball-and-stick topology or a reconstructed immatu…

Glutamatergicmedicine.anatomical_structureChemistryGABAA receptormedicineExcitatory postsynaptic potentialGABAergicDepolarizationNeuronReceptorNeuroscienceIonotropic effect
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