0000000000969698
AUTHOR
B. De Bernardi
ASPORTAZIONE DEL TUMORE PRIMITIVO NEL NEUROBLASTOMA STADIO IVs. E' UTILE NEL DECORSO CLINICO?
Lo studio si propone di valutare il ruolo dell'asportazione del tumore primitivo (TP) nei bambini in età inferiore all'anno con neuroblastoma stadio IVs
RESECTION of PRIMARY TUMOR at DIAGNOSIS in STAGE IV-s NEUROBLASTOMA: Does it Affect the Clinical Course?
To determine whether resection of primary tumor has a favorable influence on outcome of infants (age 0 to 11 months) with IV-s Neuroblastoma.
TRATTAMENTO CHIRURGICO DEL NEUROBLASTOMA IV-s
Nella casistica del Gruppo Cooperativo Italiano per il Neuroblastoma sono racolti dal 1976 al 1992 91 casi di NBstadio IV-s. Viene analizzata l'influenza della chirurgia del tumore primitivo sull'outcome di questi pazienti.
GERM CELL TUMOURS IN CHILDREN- A Report of 84 Cases
In January 1991 a Protocol for diagnosis and treatment of Germ Cell Tumours (GCT) in children was activated in 15 Italian Paediatric Centres.
RESECTION OF PRIMARY TUMOUR (PT) IN STAGE IVs NEUROBLASTOMA (NB)
The Authors report 90 cases of Children with stage IVs Neuroblastoma diagnosed in 21 Italian Istitutions. The role of surgery is examinated.
NEUROBLASTOMA INOPERABILE (NB). Esperienza deel Gruppo Cooperativo Italiano Neuroblastoma (GCNB)
Gli Autori riportano la casistica del Gruppo Coperativo Italiano Neuroblastoma ed evidenziano le forme non operabili
TUMORI A CELLULE GERMINALI IN ETA' PEDIATRICA. RISULTATI DEL PROTOCOLLO AIEOP "TG-91".
Gli Autori riportano i risultati del Protocollo AIEOP-91 presentando igli 88 casi registrati in 15 Centro AIEOP dal gGennaio 1991 al Dicembre 193
MALIGNANT GERM CELL TUMOURS in CHILDHOOD: the Italian Experience
Malignant Germ Cell Tumours (MGCT) account approximately 3% of all malignancies in the paediatric age group. Although many of them are curable, their natural history, staging, systems and optimal treatment still need to be better defined. Tha data of an Italian co-operative study are reported here
IL RUOLO DELLA CHIRURGIA NEL TRATTAMENTO DEI TUMORI GERMINALI IN ETA' PEDIATRICA: Analisi dello Studio Cooperativo "AIEOP TCG-'91.
Authors analyze the preliminary results of the first multicentric cooperative study on Germ Celkl Tumors in childhood (TCG 91). The Authors discuss the role of primary surgical procedure on the treatment of benign forms and of resectable malignant tumors.
Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study)
BACKGROUND: In neuroblastoma (NB), the presence of segmental chromosome alterations (SCAs) is associated with a higher risk of relapse. METHODS: In order to analyse the role of SCAs in infants with localised unresectable/disseminated NB without MYCN amplification, we have performed an array CGH analysis of tumours from infants enrolled in the prospective European INES trials. RESULTS: Tumour samples from 218 out of 300 enroled patients could be analysed. Segmental chromosome alterations were observed in 11%, 20% and 59% of infants enroled in trials INES99.1 (localised unresectable NB), INES99.2 (stage 4s) and INES99.3 (stage 4) (P<0.0001). Progression-free survival was poorer in patients wh…
GERM CELL TUMOURS: A Report of 72 Cases
The Authours report a prospective Study of the diagnosis and treatment of Germ Cell Tumours in children since January 1991.
TUMORI A CELLULE GERMINALI MALIGNI IN ETA’ PEDIATRICA: RISULTATI DEL II STUDIO COOPERATIVO ITALIANO TCG 98
Gli Autori presentano i risultati del Secondo Studio Cooperativo Italiano sui Tumori a Cellulle Germinali Maligni del bambino, esito del Proytocollo Nazionale TCG 98.
UNA CHIRURGIA CONSERVATIVA DEI TUMORI BENIGNI DEL TESTICOLO IN ETA' PEDIATRICA? Analisi dei Risultati di una Casistica Multicentrica Retrospettiva (1977-1987)
La Terapia Chirurgica dei tumori benigni del testicolo si basa sulla orchiectomia radicale inguinale. Tale criterio è stato messo in discussioneda alcuni Autori e per tale motivo sono stati valutati i risultati di una casistica nazionale multicentrica retrospettiva di 10 anni allo scopo di valutare la possibilità di una exeresi radicale conservativa di queste neoplasie
IL TERATOMA ED IL CHIRURGO PEDIATRA. Considerazioni sull'approccio e valutazioni dalla Casistica Nazionale "TCG 91".
Germ Cell Tumors (GCT) are rare in childhood, accounting for 2-4% of all solid neoplasms. Teratoma is the most frequent histological type (50%) of GCT and the most important neonatal tumors.. Authors analyze the results of the first Italian Multicentric Cooperative Study on GCTs in childhood (TCG 91). The role of surgical radical excision of the mass with thw coccyx in sacrococcygeal forms is streassed.
Age-dependency of the prognostic impact of tumor genomics in localized resectable MYCN non-amplified neuroblastomas Report from the SIOPEN Biology Group on the LNESG Trials
BACKGROUND: Biology based treatment reduction, i.e. surgery alone also in case of not totally resected tumors, was advised in neuroblastoma patients with localized resectable disease without MYCN amplification. However, whether the genomic background of these tumors may influence outcome was unknown and therefore scrutinized in a meta-analysis comprising two prospective therapy studies and a ‘validation’ cohort. PATIENTS AND METHODS: Diagnostic samples were derived from 406 INSS stages 1/2A/2B tumors from three cohorts: LNESGI/II and COG. Genomic data were analyzed in two age groups (cut-off: 18 months) and quality controlled by the SIOPEN Biology Group. RESULTS: In both patient age groups …
NEUROBLASTOMA A LOCALIZZAZIONE MUSCOLARE: DESCRIZIONE DI UN CASO
An unusual case of abdominal neuroblastoma, whose extention involved the psoas muscle, leading to an ultrasonographic and MRN imagin simulatinf an haematoma, is described.
THE ROLE OF SURGERY (s) IN THE TREATMENT OF GERM CELL TUMORS (GCT) IN CHILDHOOD. A Report from an Italian Multi-Istitutional Study (TCG-91)
GCT account for about 3% of all solidi Neoplasms in children. Because of the confusion as to their classification, diagnostic apporoach and treatment, a multi-istitutional study was carried and a National Protocol for Diagnosis and treatment of CGT (TCG-91), approved by AIEOP, straded in January 1991.
L'ESPLORAZIONE DEI LINFONODI REGIONALI NEL NEUROBLASTOMA LOCALIZZATO: Compliance alle Direttive Chirurgiche nello Studio Nazionale NB 85
Accurate staging of patients with Neuroblastoma is essential for prognosis and for determining the most appropriate treatment. The neoplastic involvement of regional lymph-nodes (l.n.) is an important prognostic feature; the surgical exploration of these L.n. is mandatory for localized neuroblastoma (NBL) (stage I and II) in wich surgery represent the main treatment. The Authors have carried out a retrospective analysis of the cases registered in Italy between 1985 and 1989