Olfactory xenobiotic metabolizing enzymes have an impact on the stimulating properties of some odorants

2010

International audience

Evidence for multidrug resistance transporter activity in the olfactory epithelium of rodents

2010

International audience

Odorant metabolism catalyzed by olfactory mucosal enzymes influences peripheral olfactory responses in rats.

2013

International audience; A large set of xenobiotic-metabolizing enzymes (XMEs), such as the cytochrome P450 monooxygenases (CYPs), esterases and transferases, are highly expressed in mammalian olfactory mucosa (OM). These enzymes are known to catalyze the biotransformation of exogenous compounds to facilitate elimination. However, the functions of these enzymes in the olfactory epithelium are not clearly understood. In addition to protecting against inhaled toxic compounds, these enzymes could also metabolize odorant molecules, and thus modify their stimulating properties or inactivate them. In the present study, we investigated the in vitro biotransformation of odorant molecules in the rat …

When the nose must remain responsive: glutathione conjugation of the mammary pheromone in the newborn rabbit

2014

In insects, xenobiotic-metabolizing enzymes were demonstrated to regulate pheromones inactivation, clearing them from the olfactory periphery and keeping receptors ready for stimulation renewal. Here, we investigate whether similar processes could occur in mammals, focusing on the pheromonal communication between female rabbits and their newborns. Lactating rabbits emit in their milk a volatile aldehyde, 2-methylbut-2-enal, that elicits searching-grasping in neonates; called the mammary pheromone (MP), it is critical for pups which are constrained to find nipples within the 5 min of daily nursing. For newborns, it is thus essential to remain sensitive to this odorant during the whole nursin…

Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.

2012

WOS: 000305340700029; International audience; BACKGROUND: P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP1) are membrane transporter proteins which function as efflux pumps at cell membranes and are considered to exert a protective function against the entry of xenobiotics. While evidence for Pgp and MRP transporter activity is reported for olfactory tissue, their possible interaction and participation in the olfactory response has not been investigated. PRINCIPAL FINDINGS: Functional activity of putative MDR transporters was assessed by means of the fluorometric calcein acetoxymethyl ester (calcein-AM) accumulation assay on acute rat and mouse olfactory tissue slices.…

Un modèle prédisposé d'induction de l'apprentissage chez le jeune mammifère: analyses éthologiques, neurophysiologiques et computationnelles

2007

Biotransformation of odorants modifies the olfactory signal

2009

International audience

Pyrethroids alter sodium channel gating in honeybee olfactory receptor neurons

2010

International audience; Social structure in a domestic honeybee colony relies on inter-individual. chemical communication. Chemical communication is mediated. by odors and pheromones detected by olfactory receptor. neurons (ORN) localized in antennae. The Colony Collapse Disorder. (CCD) has been described in many countries around the world. and one of its main symptoms is the desertion of the hive by adult. worker bees, leaving the queen with brood and a small number of. young bees only. Our hypothesis is that such a desertion could be a. consequence of a disruption in the colony cohesion due to a defective. peripheral olfactory system. Recent studies have shown that. several insecticides c…