0000000000971187

AUTHOR

Patrícia Rijo

showing 2 related works from this author

Enhanced Accumulation of Betulinic Acid in Transgenic Hairy Roots of Senna obtusifolia Growing in the Sprinkle Bioreactor and Evaluation of Their Bio…

2021

Betulinic acid, which is found in transgenic roots of Senna obtusifolia (L.) H.S.Irwin & Barneby, is a pentacyclic triterpene with distinctive pharmacological activities. In this study, we report the differences in the content of betulinic acid and selected anthraquinones in transgenic S. obtusifolia hairy roots with overexpression of the PgSS1 gene (SOPSS2 line) and in transformed hairy roots without this genetic construct (SOA41 line). Both hairy root lines grew in 10 L sprinkle bioreactor. Additionally, the extracts obtained from this plant material were used for biological tests. Our results demonstrated that the SOPSS2 hairy root cultures from the bioreactor showed an increase in the c…

Senna PlantTransgeneBioengineeringAnthraquinonesApoptosisMicrobial Sensitivity TestsGram-Positive BacteriaBiochemistryModels BiologicalPlant Rootschemistry.chemical_compoundBioreactorsTriterpeneGene Expression Regulation PlantBetulinic acidCell Line TumorAnthraquinonesGene expressionGram-Negative BacteriaBioreactorHumansAntiviral activityBetulinic AcidMolecular BiologyCell ProliferationPlant Proteinsbcl-2-Associated X Proteinchemistry.chemical_classificationbiologyPlant ExtractsSprinkle bioreactorGeneral ChemistryGeneral Medicinebiology.organism_classificationAntimicrobialPlants Genetically ModifiedBiodiversitatAnticancerchemistryBiochemistryGlucosyltransferasesTransgenic hairy rootsMolecular MedicineAntimicrobialGene expressionTumor Suppressor Protein p53Senna obtusifoliaPentacyclic TriterpenesChemistrybiodiversity
researchProduct

Acetylcholinesterase and antioxidant evaluation of C18-functionalized ferruginol analogues

2019

Nearly 200 years ago, the study of the chemistry of terpenoids started with the analysis of turpentine oil, investigating the first resin acid, abietic acid from pine oleoresin.[1] Abietic acid occurs in plants of the genus Abies and is the first member of a class of plant metabolites, the abietane-type diterpenoids. They are characterized by a tricyclic ring system and have shown a wide range of chemical diversity and biological activity. [2,3] Medicinal chemists have studied derivatives of two readily available materials such as dehydroabietic acid and dehydroabietylamine. [3] To date, there is only one commercial drug, Ecabet® [ecabet sodium], based on abietanes, which is used for the tr…

Ferruginolchemistry.chemical_compoundchemistryStereochemistryBiological activityResin acidReflux esophagitisAbietic acidSemisynthesisTerpenoidAbietaneProceedings of 5th International Electronic Conference on Medicinal Chemistry
researchProduct