Platelet cut-off for anticoagulant therapy in thrombocytopenic patients with blood cancer and venous thromboembolism: an expert consensus

Background. Management of venous thromboembolism (VTE) in patients with haematologic malignancies and thrombocytopenia is clinically challenging due to the related risks. No prospective studies or clinical trials have been carried out and, therefore, no solid evidence on this compelling issue is available. Methods. Given this, an expert panel endorsed by the Gruppo Italiano Malattie Ematologiche dell'Adulto Working Party on Thrombosis and Haemostasis was set up to produce a formal consensus, according to the RAND method, in order to issue clinical recommendations about the platelet (PLT) cut-off for safe administration of low molecular weight heparin (LMWH) in thrombocytopenic (PLT <100×…

Hypercoagulability during pregnancy: evidences for a thrombophilic state

The development of thrombotic disorders is a major threat for young women during pregnancy. It is one of the main causes of pregnancy-related disorders, which may also result in harm for the conceptus. Successful pregnancies require an even balance of coagulation and fibrinolysis, in order to secure stabilization of the basal plate as well as adequate placental perfusion. Broad spectrum assays which measure a range of thrombin/fibrin formation in serum have become an established means of identifying activation of blood coagulation and/or fibrinolysis. There is considerable interest in the application of these assays to the diagnosis of other hypercoagulable states, such as thrombophilia dur…

Search for K+ decays to a muon and invisible particles

The NA62 experiment at CERN reports searches for $K^+\to\mu^+N$ and $K^+\to\mu^+\nu X$ decays, where $N$ and $X$ are massive invisible particles, using the 2016-2018 data set. The $N$ particle is assumed to be a heavy neutral lepton, and the results are expressed as upper limits of ${\cal O}(10^{-8})$ of the neutrino mixing parameter $|U_{\mu4}|^2$ for $N$ masses in the range 200-384 MeV/$c^2$ and lifetime exceeding 50 ns. The $X$ particle is considered a scalar or vector hidden sector mediator decaying to an invisible final state, and upper limits of the decay branching fraction for $X$ masses in the range 10-370 MeV/$c^2$ are reported for the first time, ranging from ${\cal O}(10^{-5})$ t…

Italian daily platelet transfusion practice for haematological patients undergoing high dose chemotherapy with or without stem cell transplantation: a survey by the GIMEMA Haemostasis and Thrombosis Working Party

Background. Following high-dose chemotherapy/bone marrow transplantation, patients are routinely, prophylactically transfused with platelet concentrates (PC) if they have a platelet count ≤10×109/L or higher in the presence of risk factors for bleeding. However, whether such transfusions are necessary in clinically stable patients with no bleeding, or whether a therapeutic transfusion strategy could be sufficient and safe, is still debated. Materials and methods. The GIMEMA Haemostasis and Thrombosis Working Party sent a questionnaire to Italian haematology departments to survey several aspects of daily platelet transfusion practice, such as the cut-off platelet count for transfusion, the e…

Inhibitors to factor VII in congenital factor VII deficiency.

Work environment, volume of activity and staffing in neonatal intensive care units in Italy: results of the SONAR-nurse study

Background Neonatal units’ volume of activity, and other quantitative and qualitative variables, such as staffing, workload, work environment, care organization and geographical location, may influence the outcome of high risk newborns. Data about the distribution of these variables and their relationships among Italian neonatal units are lacking. Methods Between March 2010-April 2011, 63 neonatal intensive care units adhering to the Italian Neonatal Network participated in the SONAR Nurse study. Their main features and work environment were investigated by questionnaires compiled by the chief and by physicians and nurses of each unit. Twelve cross-sectional monthly-repeated surveys on diff…

Combined use of antifibrinolytics and activated prothrombin complex concentrate (aPCC) is not related to thromboembolic events in patients with acquired haemophilia A: data from FAIR Registry

Antifibrinolytics combined with aPCC are not routinely administered to patients with acquired hemophilia A due to increased thrombotic risk. This association normalizes clot stability, and improves the efficacy of therapy, but can increase the risk of severe side effects. Due to these premises it has always raised doubts and perplexities in the clinics. We now report the data of the "FEIBA® on acquired haemophilia A Italian Registry (FAIR Registry)", a retrospective-prospective study that included 56 patients. This is the first study that assessed the clinical response of the combination of aPCC and antifibrinolytic agents in patients with acquired haemophilia A. A total of 101 acute bleeds…

Pharmacokinetic properties of recombinant FVIIa in inherited FVII deficiency account for a large volume of distribution at steady state and a prolonged pharmacodynamic effect.

Pharmacokinetic properties of recombinant FVIIa in inherited FVII deficiency account for a large volume of distribution at steady state and a prolonged pharmacodynamic effect -

Proposal and validation of a novel quantitative approach (QUEM) for the evaluation of menstrual blood losses. Preliminary implementation for the management of menorrhagia in congenital bleeding disorders.

Menorrhagiaisaveryprevalentbleedingsymptomincongenitalbleedingdisorders(from60to100%)and in patients on OralAnticoagulants(OA),but no prospective studies are available. We here describe the validation of a new and simple method for determination of menstrual blòood losses

The beam and detector of the NA62 experiment at CERN

NA62 is a fixed-target experiment at the CERN SPS dedicated to measurements of rare kaon decays. Such measurements, like the branching fraction of the $K^{+} \rightarrow \pi^{+} \nu \bar\nu$ decay, have the potential to bring significant insights into new physics processes when comparison is made with precise theoretical predictions. For this purpose, innovative techniques have been developed, in particular, in the domain of low-mass tracking devices. Detector construction spanned several years from 2009 to 2014. The collaboration started detector commissioning in 2014 and will collect data until the end of 2018. The beam line and detector components are described together with their early …

Kaon physics at the CERN-SPS

The NA48/2 and NA62 collaborations report on recent results, current status, and prospects of kaon physics at the CERN-SPS. The NA62 collaborations aims to measure the decay [Formula: see text] with an uncertainty of 10% or better. The NA62 detector and preliminary results from a pilot run in 2014 are presented. In addition, recent results of the NA48/2 collaboration are reported. A search for Dark Photons has been performed in [Formula: see text] decays via the kaon decays [Formula: see text] and [Formula: see text]. No dark photon signal was observed and new upper limits on the mixing parameter [Formula: see text] and the dark photon mass were computed. We also report the first observati…