0000000000975856
AUTHOR
Francesco Paolo Fiorentino
BRCA1 and BRCA2 variants of uncertain clinical significance and their implications for genetic counseling
BRCA1/2 variants of uncertain clinical significance in patients with famlial and hereditary breast/ovarian cancer
Analysis of TP53, Ki-Ras and P16INK4A promoter methylation as potential prognostic factors in patients with colorectal cancer
BRCA1 and BRCA2 germline mutations in sicilian breast and/or ovarian cancer families and their association with familial profiles
EGF Induces STAT3-Dependent VEGF Expression in HT-29 colon cancer cells
Struttura di popolazione di Haliotis tuberculata in aree soggette a diversi livelli di protezione.
GENOTYPE ANALYSIS OF COLORECTAL CARCINOMAS THROUGH LASER PRESSURE CATAPULTING (LPC)
BRCA 1/2 GENES MUTATIONAL SCREENING IN SICILIAN BREAST AND/OR OVARIAN CANCER FAMILIES
BRCA 1/2 VARIANTS OF UNCERTAIN CLINICAL SIGNIFICANCE IN PATIENTS WITH FAMILIAL AND HEREDITARY BREAST/OVARIAN CANCER
Antiemetic prophylaxis containing Palonosetron (P) alone or in combination with Aprepitant (A) in the treatment of advanced soft tissue sarcoma (STS) patients with epirubicin and ifosfamide
Aplotype analysis in four sicilian families with 5083del19bp-BRCA1.
Molecular analysis of TP53, Ki-Ras and P16 methylation status in tissue and plasma of subjects affected by gastrointestinal cancer
BRCA1/BRCA2 genes mutational screening in Sicilian breast and/or ovarian cancer families.
Genotype analysis of colorectal carcinomas through laser pressare catapulting (LPC)
Recently, new chemotherapy agents which target the non-structural components of mitosis have been developed. An important protein involved in several mitotic phases is the Aurora-A protein. By means of the phosphorylation of different substrates, Aurora-A regulates the correct development of the various phases of mitosis. The kinase activity of this protein makes Aurora-A an excellent candidate as an oncogene. The first data of Aurora-A involvement in cancer regarded the identification of Aurora-A overexpression in primary breast and colon tumour samples. With regard to the predictive role of Aurora-A, it has been shown that its overexpression disrupts the spindle checkpoint activated by pa…
Human papillomavirus infection in couples undergoing in vitro fertilization procedures: impact on reproductive outcome
Analysis of Ki-Ras mutations in stage I rectal carcinomas and respective regional lymph nodes.
In this work we show that the percentage of Ki-RAS mutations in codons 12 and 13 in rectal cancer are sensibly lower than in colon cancer, providing further evidence that these two kinds of tumors should be considered two different entities. Moreover, we show that the detection in regional lymph nodes of the same mutation of primary tumor might represent an indicator of lymph nodes metastasis in rectal carcinoma not detected in routine histologic examination.
Variazioni temporali della struttura di taglia in popolazioni sfruttate di Haliotis tuberculata (Mollusca Gastropoda) nel Golfo di Sferracavallo (PA)
This study aims at evaluating the differences in size structure of population of H. tuberculata in the Gulf of Sferracavallo (northern Sicily) which experienced the co-occurrence of high exploitation and decrease of eutrophic conditions during the eighties and early nineties. Comparison of size structure showed significant differences between length frequency distributions of 1970-75s and 2002-2005, being the latter formed by smaller size green ormer.
Molecular analysis of TP53, Ki-Ras and P16 methylation status in tissue and plasma of subjects affected by gastrointestinal cancer (GIC)
BACKGROUND: Despite the improvement in detection and surgical therapy in the last years, the outcome of patients affected by colorectal carcinoma (CRC) remains limited by metastatic relapse. The aim of this study was to investigate the presence of free tumor DNA in the plasma of CRC patients in order to understand its possible prognostic role. PATIENTS AND METHODS: Ki-Ras, TP53 mutations and p16(INK4A) methylation status were prospectively evaluated in tumor tissues and plasma of 66 CRC patients. RESULTS: In 50 of the 66 primitive tumor cases (76%) at least one significant alteration was identified in Ki-Ras and/or TP53 and/or p16(INK4A) genes. Eighteen of the 50 patients presented the same…