6533b85cfe1ef96bd12bc46c

RESEARCH PRODUCT

Analysis of Ki-Ras mutations in stage I rectal carcinomas and respective regional lymph nodes.

Francesco Paolo FiorentinoValentina AgneseCalò VBruno LClaudia AugelloSandra CascioFloriana BarberaGargano GValter GregorioDonatella CalcaraLa Paglia LValentina Schiro'Marianna TerrasiDaniele FanaleLaura ScolaroGiuseppa GraceffaFrancesca Di GaudioViviana BazanAntonio RussoGiuseppe Agnello

subject

KI-RAS MUTATIONS Rectal carcinomasSettore MED/06 - Oncologia MedicaSettore MED/08 - Anatomia Patologica

description

In this work we show that the percentage of Ki-RAS mutations in codons 12 and 13 in rectal cancer are sensibly lower than in colon cancer, providing further evidence that these two kinds of tumors should be considered two different entities. Moreover, we show that the detection in regional lymph nodes of the same mutation of primary tumor might represent an indicator of lymph nodes metastasis in rectal carcinoma not detected in routine histologic examination.

yearjournalcountryeditionlanguage
2007-01-01
http://hdl.handle.net/10447/13306