0000000000010132
AUTHOR
Bruno L
DNA aneuploidy, high SPF and specific p53 mutations are independent prognostic factors in colorectale cancer (CRC)
DNA-aneuploidy and high SPF and specific p53 mutations are independent prognostic factors in colorectal cancer (CRC).
Image analysis for detecting aggregate gradation in asphalt mixture from planar images
Abstract The mechanical properties of bituminous mixture strongly depend on the gradation of the aggregate that represents the mineral skeleton of the mixture, since for open and gap-graded mixtures, stresses due to vehicles in movement on the pavement are mainly transmitted through their contacts. Internal structure of bituminous mixture is, therefore, of great interest for road and infrastructure engineering and it is appropriate to study it with recently developed image analysis method. The purpose of this study was to finalize an effective analysis of asphalt section image for automatically extracting aggregate gradation without the need of separation of the bitumen from the aggregate. …
TP53 Mutation in exon 5 and S-Phase Fraction but not Mutations in Ras gene family and DNA-ploidy are Indipendent prognostic indicators in Laryngeal Squamous Cell Carcinoma
Analysis of TP53, Ki-Ras and P16INK4A promoter methylation as potential prognostic factors in patients with colorectal cancer
Ductal Lavage: a valid method of risk assessment and of early diagnosis in breast cance
TP53 mutations are not prognostic indipendent indicators in bladder cancer
GENOTYPE ANALYSIS OF COLORECTAL CARCINOMAS THROUGH LASER PRESSURE CATAPULTING (LPC)
BRCA 1/2 GENES MUTATIONAL SCREENING IN SICILIAN BREAST AND/OR OVARIAN CANCER FAMILIES
RUOLO DI P53 E DEI GENI K-RAS EDH-RAS NELLA TUMORIGENESI DELLE GHIANDOLE SALIVARI
BRCA 1/2 VARIANTS OF UNCERTAIN CLINICAL SIGNIFICANCE IN PATIENTS WITH FAMILIAL AND HEREDITARY BREAST/OVARIAN CANCER
Aplotype analysis in four sicilian families with 5083del19bp-BRCA1.
Detection and clinical relevance of free-circulating tumor DNA in blood of patients with colorectal cancer
Improved Traffic Signal Detection and Classification via Image Processing Algorithms
An image analysis technique for automatic traffic sign detection and classification is proposed. This analysis makes it possible, after proper training, to detect, recognize and classify vertical road signs from video frames acquired on a moving vehicle equipped with cameras, as well as to identify anomalies with respect to road sign regulations (positioning and visibility). The experimental results show that this technique allows one to correctly detect and classify almost all vertical signs and, mainly in extra-urban environment, it can be considered as highly reliable, apart from being really versatile and user-friendly for road inventory and road maintenance purposes.
Molecular analysis of TP53, Ki-Ras and P16 methylation status in tissue and plasma of subjects affected by gastrointestinal cancer
BRCA1/BRCA2 genes mutational screening in Sicilian breast and/or ovarian cancer families.
Detection and clinical relevance of free circulating tumor DNA in blood of patients with gastrointestinal cancer
Genotype analysis of colorectal carcinomas through laser pressare catapulting (LPC)
Recently, new chemotherapy agents which target the non-structural components of mitosis have been developed. An important protein involved in several mitotic phases is the Aurora-A protein. By means of the phosphorylation of different substrates, Aurora-A regulates the correct development of the various phases of mitosis. The kinase activity of this protein makes Aurora-A an excellent candidate as an oncogene. The first data of Aurora-A involvement in cancer regarded the identification of Aurora-A overexpression in primary breast and colon tumour samples. With regard to the predictive role of Aurora-A, it has been shown that its overexpression disrupts the spindle checkpoint activated by pa…
Analysis of Ki-Ras mutations in stage I rectal carcinomas and respective regional lymph nodes.
In this work we show that the percentage of Ki-RAS mutations in codons 12 and 13 in rectal cancer are sensibly lower than in colon cancer, providing further evidence that these two kinds of tumors should be considered two different entities. Moreover, we show that the detection in regional lymph nodes of the same mutation of primary tumor might represent an indicator of lymph nodes metastasis in rectal carcinoma not detected in routine histologic examination.
DNA-Aneuploidy, High SPF and Specific P53 Mutations are Indipendent Prognostic Factors in Colorectal Cancer (CRC)
A.Mutational analysis of BRCA1 in sicilian patients at risk for inherited of reference center for the biomolecular characterizaztion of neoplasm and genetic screening of hereditary tumors
Molecular analysis of TP53, Ki-Ras and P16 methylation status in tissue and plasma of subjects affected by gastrointestinal cancer (GIC)
BACKGROUND: Despite the improvement in detection and surgical therapy in the last years, the outcome of patients affected by colorectal carcinoma (CRC) remains limited by metastatic relapse. The aim of this study was to investigate the presence of free tumor DNA in the plasma of CRC patients in order to understand its possible prognostic role. PATIENTS AND METHODS: Ki-Ras, TP53 mutations and p16(INK4A) methylation status were prospectively evaluated in tumor tissues and plasma of 66 CRC patients. RESULTS: In 50 of the 66 primitive tumor cases (76%) at least one significant alteration was identified in Ki-Ras and/or TP53 and/or p16(INK4A) genes. Eighteen of the 50 patients presented the same…