0000000000977186
AUTHOR
J. Nebot Martínez
Estabilidad en suero fisiológico del busulfán intravenoso en un envase de poliolefinas
Introduction: Although it has been used orally, the variability in its absorption and the risk of causing vomiting has lead to a push towards the intravenous use of bulsulfan. This study looks at the stability of 60 mg of busulfan, in fixed volumes of 250 mL (0.24 mg/mL) and 500 mL (0.12 mg/mL) of serum and different conservation conditions, in a new plastic pack made from polyolefin/polyamide laminates. Material and methods: High-efficiency liquid chromatography with ultraviolet detection was used to determine the concentration of busulfan derivate with sodium diethyldithiocarbamatetrihydrate. Stability was assessed for both concentrations; refrigerated and at room temperature, using the t…
Stability in physiological saline of intravenous busulfan in a polyolefin pack
Abstract Introduction Although it has been used orally, the variability in its absorption and the risk of causing vomiting has lead to a push towards the intravenous use of busulfan. This study looks at the stability of 60 mg of busulfan, in fixed volumes of 250 mL (0.24 mg/mL) and 500 mL (0.12 mg/mL) of physiological saline and different conservation conditions, in a new plastic pack made from polyolefin/polyamide laminates. Material and methods High-performance liquid chromatography with ultraviolet detection was used to determine the concentration of busulfan derivate with sodium diethyldithiocarbamate trihydrate. Stability was assessed for both concentrations; refrigerated and at room t…