0000000000977444

AUTHOR

Purificación Ruiz

showing 2 related works from this author

Stereoselective synthesis of the naturally occurring styryllactones (+)-goniofufurone and (+)-cardiobutanolide.

2004

The naturally occurring gamma-lactones (+)-goniofufurone 1 and (+)-cardiobutanolide 2, two pharmacologically active products from Goniothalamus species (Annonaceae), have been synthesized in enantiopure form using l-erythrulose as the chiral starting material. Key steps of these syntheses were a stereoselective anti boron aldol reaction and an asymmetric allylboration.

GlycerolMagnetic Resonance SpectroscopybiologyMolecular StructureStereochemistryChemistryOrganic ChemistryEnantioselective synthesisAnnonaceaeStereoisomerismStereoisomerismbiology.organism_classificationChemical synthesisLactonesEnantiopure drugAldol reaction4-ButyrolactoneOrganic chemistryAldol condensationStereoselectivityGoniothalamusThe Journal of organic chemistry
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Stereoselective anti aldol reactions of erythrulose derivatives. Functionalized chiral d3 and d4 synthons.

2004

An improved procedure for the synthesis of anti aldols from protected erythrulose derivatives is reported. The preparation of functionalized d3 and d4 synthons with various stereochemical arrays by means of this methodology is described and subsequently applied to a stereoselective formal synthesis of the natural metabolite goniothalesdiol.

AldehydesMolecular StructureStereochemistryMetaboliteOrganic ChemistrySynthonStereoisomerismErythruloseStereoisomerismKetonesChemical synthesischemistry.chemical_compoundLactoneschemistryAldol reactionStereoselectivityAldol condensationTetrosesThe Journal of organic chemistry
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