6533b855fe1ef96bd12b080e
RESEARCH PRODUCT
Stereoselective synthesis of the naturally occurring styryllactones (+)-goniofufurone and (+)-cardiobutanolide.
J. Alberto MarcoPurificación RuizMiguel CardaJuan Murgasubject
GlycerolMagnetic Resonance SpectroscopybiologyMolecular StructureStereochemistryChemistryOrganic ChemistryEnantioselective synthesisAnnonaceaeStereoisomerismStereoisomerismbiology.organism_classificationChemical synthesisLactonesEnantiopure drugAldol reaction4-ButyrolactoneOrganic chemistryAldol condensationStereoselectivityGoniothalamusdescription
The naturally occurring gamma-lactones (+)-goniofufurone 1 and (+)-cardiobutanolide 2, two pharmacologically active products from Goniothalamus species (Annonaceae), have been synthesized in enantiopure form using l-erythrulose as the chiral starting material. Key steps of these syntheses were a stereoselective anti boron aldol reaction and an asymmetric allylboration.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-12-15 | The Journal of organic chemistry |