0000000000984993

AUTHOR

Philippe Decorse

showing 2 related works from this author

Grafting TRAIL through Either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency

2021

International audience; Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF cytokine superfamily. TRAIL is able to induce apoptosis through engagement of its death receptors DR4 and DR5 in a wide variety of tumor cells while sparing vital normal cells. This makes it a promising agent for cancer therapy. Here, we present two different ways of covalently grafting TRAIL onto maghemite nanoparticles (NPs): (a) by using carboxylic acid groups of the protein to graft it onto maghemite NPs previously functionalized with amino groups, and (b) by using the amino functions of the protein to graft it onto NPs functionalized with carboxylic acid groups. The two …

Molecular modelGeneral Chemical EngineeringCarboxylic acidmedicine.medical_treatment02 engineering and technologyArticlelcsh:Chemistry03 medical and health sciencesmedicine[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyGeneral Materials Science[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyViability assaycancer diseasecell viability030304 developmental biologysurface functionalizationchemistry.chemical_classification0303 health sciencesChemistrymolecular modelingtechnology industry and agriculture021001 nanoscience & nanotechnologyLigand (biochemistry)3. Good healthmaghemiteCytokinelcsh:QD1-999BiochemistryApoptosisCell cultureTumor necrosis factor alpha0210 nano-technology
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A comparative study of the surface and bulk properties of lanthanum-strontium-manganese oxides La1−xSrxMnO3±δ as a function of Sr-content, oxygen…

1999

Abstract The properties of the perovskite-type La 1− x Sr x MnO 3± δ oxides (0≤ x ≤1) are related to the reversible redox reaction of manganese ions Mn 3+ ↔Mn 4+ . This reaction plays an essential role both in the interfacial transfers and transport properties and depends on relative cation concentrations and experimental conditions. In this paper we present experimental investigations aiming to determine, to compare and to control some of the surface and bulk properties of these oxides. The bulk and surface Mn 4+ contents were investigated by thermogravimetry analysis (TGA) in hydrogen and X-ray photo-electron spectroscopy (XPS) respectively. With a finely divided La 0.8 Sr 0.2 MnO 3 powde…

StrontiumInorganic chemistrychemistry.chemical_elementGeneral ChemistryManganeseCondensed Matter PhysicsOxygenRedoxThermogravimetrychemistryOxidation stateLanthanumGeneral Materials ScienceChemical compositionSolid State Ionics
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