0000000000988726

AUTHOR

Munemitsu Yoshikawa

showing 1 related works from this author

When do myopia genes have their effect? Comparison of genetic risks between children and adults

2016

Item does not contain fulltext Previous studies have identified many genetic loci for refractive error and myopia. We aimed to investigate the effect of these loci on ocular biometry as a function of age in children, adolescents, and adults. The study population consisted of three age groups identified from the international CREAM consortium: 5,490 individuals aged 25 years. All participants had undergone standard ophthalmic examination including measurements of axial length (AL) and corneal radius (CR). We examined the lead SNP at all 39 currently known genetic loci for refractive error identified from genome-wide association studies (GWAS), as well as a combined genetic risk score (GRS). …

0301 basic medicineAdultMalemedicine.medical_specialtyBiometryAdolescentGenotypeEpidemiologySingle-nucleotide polymorphismGenome-wide association studyBiologyPolymorphism Single NucleotideConnexinsSensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]03 medical and health sciencesYoung Adult0302 clinical medicineRisk FactorsInternal medicineGenotypemedicineMyopiaSNPHumansAlleleYoung adult610 Medicine & healthChildGenetics (clinical)AllelesGenetic associationGenetics030104 developmental biologyGenetic Loci030221 ophthalmology & optometryPopulation studyFemaleRELamininGenome-Wide Association Study
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