0000000000988959
AUTHOR
Fabio Rizzo
LA CICOGNA BIANCA CICONIA CICONIA (Aves Ciconiidae) IN SICILIA: AGGIORNAMENTO A TRENT'ANNI DALLA COLONIZZAZIONE
Il presente lavoro sintetizza le conoscenze sulla Cicogna bianca nidificante in Sicilia negli ultimi 29 anni, dal 1991 (anno della prima nidificazione) al 2020. Per la raccolta dei dati sono state seguite le linee guida dell’International White Stork Census. Vengono presentate una cartina di distribuzione che illustra l’areale della specie attraverso un confronto temporale e alcune tabelle relative all’andamento annuale delle coppie nidificanti in Sicilia (sia HPa che HPm), al numero dei pulli involati e alla media (±SD) per nido. Dopo una crescita della popolazione nidificante, da una coppia fino a un massimo di 82 nel 2013, si è avuto un leggero calo e il numero di nidi si è stabilizzato …
The resistance related to targeted therapy in malignant pleural mesothelioma: Why has not the target been hit yet?
Abstract: Malignant pleural mesothelioma (MPM) is an aggressive tumor of the pleura with a poor prognosis. The most active first-line regimens are platinum compounds and pemetrexed. There is no standard second-line treatment in MPM. Advances in the understanding of tumor molecular biology have led to the development of several targeted treatments, which have been evaluated in clinical trials. Unfortunately none of the explored targeted treatments can currently be recommended as routine treatment in MPM. We reviewed the biological pathways involved in MPM, the clinical trials about targeted therapy, and possible related mechanisms of resistance. We suggest that specific genetic markers are n…
Isolated Metachronous Splenic Metastasis from Colon Cancer: Possible Explanations for This Rare Entity
The incidence of splenic metastases secondary to colorectal cancer is very low; these lesions have been more frequently reported as secondary to breast, lung, and ovarian cancer. Splenic metastases are particularly common in melanoma; their incidence has been reported as being as high as 34% at autopsy [1]. Most cases of secondary splenic metastases have been described in patients with tumors of the left colon while only few cases being reported as originating from right colon tumors (Table 1). The finding of a splenic mass in the absence of a history of malignancy suggests a primary lesion (lymphoma, hematoma, etc.), while a history of oncological disease raises the possibility of a second…