0000000000998394
AUTHOR
A. Melzer
TRANS-FUSIMO: Preliminary in-vivo animal results of MR-guided Focused Ultrasound of liver under respiratory motion
Background: Treating liver tumors using FUS poses a great challenge due to the respiratory motion of the target and by the rib cage obscuring the anatomical location of the malignancy. In the EU FP7 project TRANS-FUSIMO (www.trans-fusimo.eu) a novel treatment software has been developed to support MR guided focused ultrasound treatment of liver lesions through electronic real-time beam steering of the ultrasound transducer. Prior to clinical use we conduct an in-vivo animal trial using the TRANS-FUSIMO treatment system (TTS) to evaluate the safety and the technical efficacy and efficiency of generation predefined necrotic lesions in the healthy liver. Material and Methods: The pre-clinical …
Performance of the upgraded PreProcessor of the ATLAS Level-1 Calorimeter Trigger
The PreProcessor of the ATLAS Level-1 Calorimeter Trigger prepares the analogue trigger signals sent from the ATLAS calorimeters by digitising, synchronising, and calibrating them to reconstruct transverse energy deposits, which are then used in further processing to identify event features. During the first long shutdown of the LHC from 2013 to 2014, the central components of the PreProcessor, the Multichip Modules, were replaced by upgraded versions that feature modern ADC and FPGA technology to ensure optimal performance in the high pile-up environment of LHC Run 2. This paper describes the features of the newMultichip Modules along with the improvements to the signal processing achieved.
Die endoskopisch-mikrochirurgische Dissektion der Speiseröhre — Tierexperimentelle Ergebnisse
Ist in der Behandlung von gutartigen oder malignen Speiserohrenerkrankungen die Entfernung des Oesophagus erforderlich, so gilt die stumpfe Dissektion im Gegensatz zum Zweihohleneingriff als das weniger invasive Verfahren. Der Nachteil liegt in der fehlenden Sicht wahrend der Praparation mit daraus resultierendem unkontrollierten Blutverlust, unerkannten Trachealverletzungen und Lasionen des linken Nervus recurrens, die in der Literatur mit bis zu 40% angegeben werden (2, 4, 5).
Observation and Measurement of Forward Proton Scattering in Association with Lepton Pairs Produced via the Photon Fusion Mechanism at ATLAS
The observation of forward proton scattering in association with lepton pairs (eþe− þ p or μþμ− þ p) produced via photon fusion is presented. The scattered proton is detected by the ATLAS Forward Proton spectrometer, while the leptons are reconstructed by the central ATLAS detector. Proton-proton collision data recorded in 2017 at a center-of-mass energy of ffiffiffi s p ¼ 13 TeV are analyzed, corresponding to an integrated luminosity of 14.6 fb−1. A total of 57 (123) candidates in the ee þ p (μμ þ p) final state are selected, allowing the background-only hypothesis to be rejected with a significance exceeding 5 standard deviations in each channel. Proton-tagging techniques are introduced f…
TRANS-FUSIMO – A novel system for treatment support for FUS applications in moving abdominal organs
Computer based treatemnt support for FUS therapy of moviving abdominal organs is essential due to great intrinsic challenges: the target moves due to breathing and may be occluded by the rib cage. In the EU project TRANS-FUSIMO we have developed a sophisticated software system that connects to a FUS transducer and an MRI. This enables physicians to conduct safe, effective and efficient ablation of tumors in the moving liver.
TRANS-FUSIMO: preliminary in-vivo animal results of MR-guided focused ultrasound of liver under respiratory motion
Purpose: Treating liver tumors using Focused Ultrasound (FUS) is a great challenge. Prior to human applications, an in-vivo animal trial using the TRANS-FUSIMO treatment system (TTS) is ongoing in order to evaluate the safety and the technical efficacy and efficiency of generating predefined necrotic lesions. Methods and Materials: The trial includes a crossbred porcine model of thirty large white swine (all females; 55-85Kg) that will be treated using the TTS under general anaesthesia with intubation. All treatments haven been performed under ventilator-controlled breathing and using an improved non-clinical prototype FUS transducer integrated with a 1,5T MRI unit; a set of interventional …
Measurement of photon?jet transverse momentum correlations in 5.02 TeV Pb + Pb and pp collisions with ATLAS
Jets created in association with a photon can be used as a calibrated probe to study energy loss in the medium created in nuclear collisions. Measurements of the transverse momentum balance between isolated photons and inclusive jets are presented using integrated luminosities of 0.49 nb−1 of Pb + Pb collision data at TeV and 25 pb−1 of pp collision data at TeV recorded with the ATLAS detector at the LHC. Photons with transverse momentum GeV and are paired with all jets in the event that have GeV and pseudorapidity . The transverse momentum balance given by the jet-to-photon ratio, , is measured for pairs with azimuthal opening angle . Distributions of the per-photon jet yield as a function…