Diez años de investigación traslacional colaborativa en enfermedades mentales: el CIBERSAM

Propiedades psicométricas de la versión española de la Philadelphia Mindfulness Scale

Resumen Introduccion La Philadelphia Mindfulness Scale (PHLMS) es un cuestionario breve que evalua 2 componentes clave de la atencion plena: la conciencia en el momento presente y la aceptacion. El presente estudio evalua las propiedades psicometricas de la version espanola de la PHLMS tanto en una muestra control de estudiantes universitarios como en poblacion con patologia psiquiatrica. Material y metodos Se administro la version espanola de la PHLMS a 395 voluntarios (256 con patologia psiquiatrica y 139 estudiantes). Resultados El analisis factorial exploratorio de la version espanola de la PHLMS apoya la solucion bifactorial de la version original con una varianza explicada del 44,02%.…

AN EFFECTIVE NEUROFEEDBACK TRAINING, WITH CORTISOL CORRELATES, IN A CLINICAL CASE OF ANXIETY

Background and objectives: Neurofeedback treatments have shown successful results in anxiety disorders. Thus, the effectiveness of a beta1 Neurofeedback protocol was tested in a longitudinal clinical case study. Design and methods: A participant suffering from an anxiety syndrome was treated with 10 sessions of Neurofeedback, which protocol consisted in uptraining beta1 rhythm (16-21 Hz) while downtraining theta (4-8 Hz) band. For each of the 10 sessions the state anxiety and salivary cortisol levels were measured in a pre/post design. Initial and final examinations of anxiety symptoms and sustained attention performance were taken in addition. 
 Results: The final evaluation showed th…

Efectividad de un entrenamiento asistido por Neurofeedback, con correlatos de cortisol, en un caso clínico de ansiedad

Neurofeedback treatments have shown successful results in anxiety disorders. The effectiveness of a betal Neurofeedback protocol was tested in a longitudinal clinical case study. A participant suffering from an anxiety syndrome underwent 10 sessions of Neurofeedback, in a protocol consisting of uptraining the betal rhythm (16-21 Hz) while downtraining the theta (4-8 Hz) band. State anxiety and salivary cortisol levels were measured during each of the 10 sessions following a pre/post design. Initial and final examinations of anxiety symptoms and sustained attention performance were also implemented. The final evaluation revealed that levels of anxiety fell within a normative range and that s…

Replication of previous genome-wide association studies of psychiatric diseases in a large schizophrenia case-control sample from Spain.

Genome wide association studies (GWAS) has allowed the discovery of some interesting risk variants for schizophrenia (SCZ). However, this high-throughput approach presents some limitations, being the most important the necessity of highly restrictive statistical corrections as well as the loss of statistical power inherent to the use of a Single Nucleotide Polymorphism (SNP) analysis approach. These problems can be partially solved through the use of a polygenic approach. We performed a genotyping study in SCZ using 86 previously associated SNPs identified by GWAS of SCZ, bipolar disorder (BPD) and autistic spectrum disorder (ASD) patients. The sample consisted of 3063 independent cases wit…