Experimental Evidence for an Attractive p-φ Interaction

Physical review letters 127(17), 172301 (2021). doi:10.1103/PhysRevLett.127.172301

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma

Recurrent mutations in chromatin modifiers are specifically prevalent in adolescent or adult patients with Sonic hedgehog-associated medulloblastoma (SHH MB). Here, we report that mutations in the acetyltransferase CREBBP have opposing effects during the development of the cerebellum, the primary site of origin of SHH MB. Our data reveal that loss of Crebbp in cerebellar granule neuron progenitors (GNPs) during embryonic development of mice compromises GNP development, in part by downregulation of brain-derived neurotrophic factor (Bdnf). Interestingly, concomitant cerebellar hypoplasia was also observed in patients with Rubinstein-Taybi syndrome, a congenital disorder caused by germline mu…

IRIDE: Interdisciplinary research infrastructure based on dual electron linacs and lasers

This paper describes the scientific aims and potentials as well as the preliminary technical design of RUDE, an innovative tool for multi-disciplinary investigations in a wide field of scientific, technological and industrial applications. IRIDE will be a high intensity "particles factory", based on a combination of high duty cycle radio-frequency superconducting electron linacs and of high energy lasers. Conceived to provide unique research possibilities for particle physics, for condensed matter physics, chemistry and material science, for structural biology and industrial applications, IRIDE will open completely new research possibilities and advance our knowledge in many branches of sci…

Six-dimensional measurements of trains of high brightness electron bunches

Trains of ultrashort electron pulses with THz repetition rate, so-called comblike beams, are assuming an ever growing interest in plasma-based acceleration. In particle-driven plasma wakefield acceleration (PWFA), a train of driver bunches with separation of the order of plasma wavelength, i.e., 300 μm, resonantly excites a plasma wake, which accelerates a trailing witness bunch, injected at the accelerating phase. Comblike beams have great potentialities in different fields of applications. In particular, radiation sources, such as free-electron lasers and THz radiation, take advantage from the possibility to tailor electron beams modulated both in time and energy, to customize emission ba…

Measurement of PromptD-Meson Production inp−PbCollisions atsNN=5.02  TeV

The p_{T}-differential production cross sections of the prompt charmed mesons D^{0}, D^{+}, D^{*+}, and D_{s}^{+} and their charge conjugate in the rapidity interval -0.96<y_{cms}<0.04 were measured in p-Pb collisions at a center-of-mass energy sqrt[s_{NN}]=5.02 TeV with the ALICE detector at the LHC. The nuclear modification factor R_{pPb}, quantifying the D-meson yield in p-Pb collisions relative to the yield in pp collisions scaled by the number of binary nucleon-nucleon collisions, is compatible within the 15%-20% uncertainties with unity in the transverse momentum interval 1<p_{T}<24 GeV/c. No significant difference among the R_{pPb} of the four D-meson species is observed. The results…

Role of cardiac dyssynchrony and resynchronization therapy in functional mitral regurgitation

Functional mitral regurgitation (FMR) is a common complication of left ventricle (LV) dysfunction and remodelling. Recently, it has been recognized as an independent prognostic factor in both ischaemic and non-ischaemic LV dysfunctions. In this review article, we discuss the mechanisms through which cardiac dyssynchrony is involved in FMR pathophysiologic cascade and how cardiac resynchronization therapy (CRT) can have therapeutic effects on FMR by reverting specific dyssynchrony pathways. We analyse recent clinical trials focusing on CRT impact on FMR in 'real-world' patients, the limits and future perspectives that could eventually generate new predictors of CRT response in terms of FMR r…

Fluticasone propionate/formoterol: a fixed-combination therapy with flexible dosage.

International guidelines describe asthma control as the main outcome of asthma management. Prevention of symptoms, improved quality of life, and reduction of exacerbations are the main components, consequently decreasing health care costs. However, many of these objectives remain unmet in real life: several surveys show that a large proportion of asthmatic patients are not well controlled despite the efficacy of current available treatment. Several randomized controlled clinical trials indicate that combining inhaled corticosteroids and long-acting β2-agonists, by means of a single inhaler, greatly improves the management of the disease. The results of 9 multicenter phase III clinical studi…

Production of Muons from Heavy Flavor Decays at Forward Rapidity inppand Pb-Pb Collisions atsNN=2.76  TeV

The ALICE Collaboration has measured the inclusive production of muons from heavy-flavor decays at forward rapidity, 2.5 < y < 4, in pp and Pb-Pb collisions at root s(NN) = 2.76 TeV. The p(t)-differential inclusive cross section of muons from heavy-flavor decays in pp collisions is compared to perturbative QCD calculations. The nuclear modification factor is studied as a function of p(t) and collision centrality. A weak suppression is measured in peripheral collisions. In the most central collisions, a suppression of a factor of about 3-4 is observed in 6 < p(t) < 10 GeV/c. The suppression shows no significant p(t) dependence.

Kaon-proton strong interaction at low relative momentum via femtoscopy in Pb-Pb collisions at the LHC

Physics letters / B 822, 136708 (2021). doi:10.1016/j.physletb.2021.136708

Left ventricular hypertrophy or storage disease? the incremental value of speckle tracking strain bull's-eye

Left ventricular hypertrophy (LVH) develops in response to a variety of physical, genetic, and biochemical stimuli and represents the early stage of ventricular remodeling. In patients with LVH, subclinical left ventricular (LV) dysfunction despite normal ejection fraction (EF) may be present before the onset of symptoms, which portends a dismal prognosis. Strain measurement with two-dimensional speckle tracking echocardiography (STE) represents a highly reproducible and accurate alternative to LVEF determination. The present review focuses on current available evidence that supports the incremental value of STE in the diagnostic and prognostic workup of LVH. When assessing the components o…

Azimuthal anisotropy ofD-meson production in Pb-Pb collisions atsNN=2.76TeV

The production of the prompt charmed mesons D0, D+, and D*+ relative to the reaction plane was measured in Pb-Pb collisions at a center-of-mass energy per nucleon-nucleon collision of √sNN=2.76TeV with the ALICE detector at the CERN Large Hadron Collider. D mesons were reconstructed via their hadronic decays at central rapidity in the transverse-momentum (p_T) interval 2–16 GeV/c. The azimuthal anisotropy is quantified in terms of the second coefficient v2 in a Fourier expansion of the D-meson azimuthal distribution and in terms of the nuclear modification factor R_AA, measured in the direction of the reaction plane and orthogonal to it. The v2 coefficient was measured with three different …

Study of very forward energy and its correlation with particle production at midrapidity in pp and p-Pb collisions at the LHC

Journal of high energy physics 08(8), 86 (2022). doi:10.1007/JHEP08(2022)086

Outcomes of Patients With Asymptomatic Aortic Stenosis Followed Up in Heart Valve Clinics

International audience; Importance - The natural history and the management of patients with asymptomatic aortic stenosis (AS) have not been fully examined in the current era. Objective - To determine the clinical outcomes of patients with asymptomatic AS using data from the Heart Valve Clinic International Database. Design, setting, and participants - This registry was assembled by merging data from prospectively gathered institutional databases from 10 heart valve clinics in Europe, Canada, and the United States. Asymptomatic patients with an aortic valve area of 1.5 cm2 or less and preserved left ventricular ejection fraction (LVEF) greater than 50% at entry were considered for the prese…

Measurement of electrons from semileptonic heavy-flavor hadron decays inppcollisions ats=2.76  TeV

The pT-differential production cross section of electrons from semileptonic decays of heavy-flavor hadrons has been measured at midrapidity in proton-proton collisions at s=2.76TeV in the transverse momentum range 0.5<pT<12GeV/c with the ALICE detector at the LHC. The analysis was performed using minimum bias events and events triggered by the electromagnetic calorimeter. Predictions from perturbative QCD calculations agree with the data within the theoretical and experimental uncertainties.

Jet-associated deuteron production in pp collisions at s=13 TeV

Author(s): Acharya, S; Adamova, D; Adler, A; Adolfsson, J; Aglieri Rinella, G; Agnello, M; Agrawal, N; Ahammed, Z; Ahmad, S; Ahn, SU; Akbar, Z; Akindinov, A; Al-Turany, M; Albuquerque, DSD; Aleksandrov, D; Alessandro, B; Alfanda, HM; Alfaro Molina, R; Ali, B; Ali, Y; Alici, A; Alizadehvandchali, N; Alkin, A; Alme, J; Alt, T; Altenkamper, L; Altsybeev, I; Anaam, MN; Andrei, C; Andreou, D; Andronic, A; Angeletti, M; Anguelov, V; Anticic, T; Antinori, F; Antonioli, P; Apadula, N; Aphecetche, L; Appelshauser, H; Arcelli, S; Arnaldi, R; Arratia, M; Arsene, IC; Arslandok, M; Augustinus, A; Averbeck, R; Aziz, S; Azmi, MD; Badala, A; Baek, YW; Bai, X; Bailhache, R; Bala, R; Balbino, A; Baldisseri, …

Multi-particle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider

Measurements of multi-particle azimuthal correlations (cumulants) for charged particles in p-Pb and Pb-Pb collisions are presented. They help address the question of whether there is evidence for global, flow-like, azimuthal correlations in the p-Pb system. Comparisons are made to measurements from the larger Pb-Pb system, where such evidence is established. In particular, the second harmonic two-particle cumulants are found to decrease with multiplicity, characteristic of a dominance of few-particle correlations in p-Pb collisions. However, when a $|\Delta \eta|$ gap is placed to suppress such correlations, the two-particle cumulants begin to rise at high-multiplicity, indicating the prese…

Constraints on jet quenching in p–Pb collisions at sNN=5.02 TeV measured by the event-activity dependence of semi-inclusive hadron-jet distributions

The ALICE Collaboration reports the measurement of semi-inclusive distributions of charged-particle jets recoiling from a high-transverse momentum trigger hadron in p–Pb collisions at √sNN = 5.02 TeV. Jets are reconstructed from charged-particle tracks using the anti-kT algorithm with resolution parameter R = 0.2 and 0.4. A data-driven statistical approach is used to correct the uncorrelated background jet yield. Recoil jet distributions are reported for jet transverse momentum 15 < pch T,jet < 50 GeV/c and are compared in various intervals of p–Pb event activity, based on charged-particle multiplicity and zero-degree neutral energy in the forward (Pb-going) direction. The semi-inclusive ob…

Unveiling the strong interaction among hadrons at the LHC

One of the key challenges for nuclear physics today is to understand from first principles the effective interaction between hadrons with different quark content. First successes have been achieved using techniques that solve the dynamics of quarks and gluons on discrete space-time lattices1,2. Experimentally, the dynamics of the strong interaction have been studied by scattering hadrons off each other. Such scattering experiments are difficult or impossible for unstable hadrons3–6 and so high-quality measurements exist only for hadrons containing up and down quarks7. Here we demonstrate that measuring correlations in the momentum space between hadron pairs8–12 produced in ultrarelativistic…

Revising old principles of inhaled treatment in new fixed combinations for asthma.

The major influencing factors on persistent asthma control are the selected treatment(s), the drug delivery route and patient's adherence to therapy, together with the influence of lifestyle (i.e. sedentary habit), comorbid conditions and specific asthma phenotypes. Inhaled corticosteroids (ICS) in combination with a long-acting β2-agonist (LABA) are the gold standard for management of persistent asthma, with maximal local targeting and minimal systemic side effects. Several innovative inhaler devices have been developed for effective local drug administration and good patient compliance to therapy. Recently, a new ICS/LABA fixed combination, formulated with fluticasone propionate (FP) and …

LABA/LAMA fixed-dose combinations in patients with COPD: a systematic review

Paola Rogliani,1 Luigino Calzetta,1 Fulvio Braido,2 Mario Cazzola,1 Enrico Clini,3 Girolamo Pelaia,4 Andrea Rossi,5 Nicola Scichilone,6 Fabiano Di Marco7 1Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy; 2Department of Internal Medicine, IRCCS San Martino Genoa University Hospital, Genoa, Italy; 3Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Department of Medical and Surgical Sciences, Section of Respiratory Diseases, Magna Gr&amp;aelig;cia University, Catanzaro, Italy; 5Pulmonary Unit, University of Verona, Verona, Italy; 6Department of Internal Medicine, University of Palermo, Palermo, Ital…

Search for collectivity with azimuthal J/ψ-hadron correlations in high multiplicity p–Pb collisions at sNN=5.02 and 8.16 TeV

A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation (ANSL), State Committee of Science and World Federation of Scientists (WFS), Armenia; Austrian Academy of Sciences and Nationalstiftung fur Forschung, Technologie und Entwicklung, Austria; Ministry of Communications and High Technologies, National Nuclear Research Center, Azerbaijan; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Universidade Federal do Rio Grande do Sul (UFRGS), Financiadora de Estudos e Projetos (Finep) and Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil; Ministry of Science & Technology of China (MSTC), National Natural Science Foundation of Chi…

Λc+ Production and Baryon-to-Meson Ratios in pp and p -Pb Collisions at sNN=5.02  TeV at the LHC

The prompt production of the charm baryon Λ c + and the Λ c + / D 0 production ratios were measured at midrapidity with the ALICE detector in p p and p -Pb collisions at s NN = 5.02 TeV . These new measurements show a clear decrease of the Λ c + / D 0 ratio with increasing transverse momentum ( p T ) in both collision systems in the range 2 p T 12 GeV / c , exhibiting similarities with the light-flavor baryon-to-meson ratios p / π and Λ / K S 0 . At low p T , predictions that include additional color-reconnection mechanisms beyond the leading-color approximation, assume the existence of additional higher-mass charm-baryon states, or include hadronization via coalescence can describe the dat…

Drug Prescription and Delirium in Older Inpatients: Results From the Nationwide Multicenter Italian Delirium Day 2015-2016

Objective This study aimed to evaluate the association between polypharmacy and delirium, the association of specific drug categories with delirium, and the differences in drug-delirium association between medical and surgical units and according to dementia diagnosis. Methods Data were collected during 2 waves of Delirium Day, a multicenter delirium prevalence study including patients (aged 65 years or older) admitted to acute and long-term care wards in Italy (2015-2016); in this study, only patients enrolled in acute hospital wards were selected (n = 4,133). Delirium was assessed according to score on the 4 "A's" Test. Prescriptions were classified by main drug categories; polypharmacy w…

Multiplicity dependence of jet-like two-particle correlation structures in p–Pb collisions at sNN=5.02 TeV

Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum range 0.7<pT,assoc<pT,trig<5.0 GeV/c is examined, to include correlations induced by jets originating from low momentum-transfer scatterings (minijets). The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range |η|<0.9. The near-side long-range pseudorapidity correlations observed in high-multiplicity p-Pb collisions are subtracted from both near-side short-range and away-side correlations in order to remove the no…

First measurement of quarkonium polarization in nuclear collisions at the LHC

The polarization of inclusive J/$\psi$ and $\Upsilon(1{\rm S})$ produced in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}=5.02$ TeV at the LHC is measured with the ALICE detector. The study is carried out by reconstructing the quarkonium through its decay to muon pairs in the rapidity region $2.5<y<4$ and measuring the polar and azimuthal angular distributions of the muons. The polarization parameters $\lambda_{\theta}$, $\lambda_{\phi}$ and $\lambda_{\theta\phi}$ are measured in the helicity and Collins-Soper reference frames, in the transverse momentum interval $2<p_{\rm T}<10$ GeV/$c$ and $p_{\rm T}<15$ GeV/$c$ for the J/$\psi$ and $\Upsilon(1{\rm S})$, respectively. The polarization parameter…

First study of the two-body scattering involving charm hadrons

Physical review / D 106(5), 052010 (2022). doi:10.1103/PhysRevD.106.052010

Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience.

Some studies have shown that fetal outcome observed in patients using insulin lispro is much the same as in pregnant women using regular insulin. This study aims to analyze the Italian data emerging from a multinational, multicenter, retrospective study on mothers with type 1 diabetes mellitus before pregnancy, comparing those treated with insulin lispro for at least 3 months before and 3 months after conception with those treated with regular insulin. The data collected on pregnant women with diabetes attending 15 Italian centers from 1998 to 2001 included: HbA1c at conception and during the first and third trimesters, frequency of severe hypoglycemic episodes, spontaneous abortions, mode …

XStrain 4D analysis predicts left ventricular remodeling in patients with recent non-ST-segment elevation myocardial infarction

Inclusive heavy-flavour production at central and forward rapidity in Xe–Xe collisions at TeV

The first measurements of the production of muons and electrons from heavy-flavour hadron decays in Xe–Xe collisions at sNN=5.44 TeV, using the ALICE detector at the LHC, are reported. The measurement of the nuclear modification factor RAA is performed as a function of transverse momentum pT in several centrality classes at forward rapidity (2.5&lt;y&lt;4) and midrapidity (|y|&lt;0.8) for muons and electrons from heavy-flavour hadron decays, respectively. A suppression by a factor up to about 2.5 compared to the binary-scaled pp reference is observed in central collisions at both central and forward rapidities. The RAA of muons from heavy-flavour hadron decays is compared to previous measur…

Two-Color Radiation Generated in a Seeded Free-Electron Laser with Two Electron Beams.

We present the experimental evidence of the generation of coherent and statistically stable two-color free-electron laser radiation obtained by seeding an electron beam double peaked in energy with a laser pulse single spiked in frequency. The radiation presents two neat spectral lines, with time delay, frequency separation, and relative intensity that can be accurately controlled. The analysis of the emitted radiation shows a temporal coherence and a shot-to-shot regularity in frequency significantly enhanced with respect to the self-amplified spontaneous emission. © 2015 American Physical Society. © 2015 American Physical Society.

Investigations of Anisotropic Flow Using Multiparticle Azimuthal Correlations in pp, p-Pb, Xe-Xe, and Pb-Pb Collisions at the LHC

Measurements of anisotropic flow coefficients ($v_n$) and their cross-correlations using two- and multi-particle cumulant methods are reported in collisions of pp at $\sqrt{s} = 13$ TeV, p-Pb at $\sqrt{s_{_{\rm NN}}} = 5.02$ TeV, Xe-Xe at $\sqrt{s_{_{\rm NN}}} = 5.44$ TeV, and Pb-Pb at $\sqrt{s_{_{\rm NN}}} = 5.02$ TeV recorded with the ALICE detector. The multiplicity dependence of $v_n$ is studied in a very wide range from 20 to 3000 particles produced in the mid-rapidity region $|��|&lt;0.8$ for the transverse momentum range $0.2 &lt; p_{\rm T} &lt; 3.0$ GeV/$c$. An ordering of the coefficients $v_2 &gt; v_3 &gt; v_4$ is found in pp and p-Pb collisions, similar to that seen in large coll…

LABA/LAMA fixed-dose combinations in patients with COPD: A systematic review

Paola Rogliani,1 Luigino Calzetta,1 Fulvio Braido,2 Mario Cazzola,1 Enrico Clini,3 Girolamo Pelaia,4 Andrea Rossi,5 Nicola Scichilone,6 Fabiano Di Marco7 1Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy; 2Department of Internal Medicine, IRCCS San Martino Genoa University Hospital, Genoa, Italy; 3Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Department of Medical and Surgical Sciences, Section of Respiratory Diseases, Magna Gr&aelig;cia University, Catanzaro, Italy; 5Pulmonary Unit, University of Verona, Verona, Italy; 6Department of Internal Medicine, University of Palermo, Palermo, Italy; 7…

Charm-quark fragmentation fractions and production cross section at midrapidity in pp collisions at the LHC

Physical review / D 105(1), L011103 (2022). doi:10.1103/PhysRevD.105.L011103

The THESEUS space mission concept: science case, design and expected performances

THESEUS is a space mission concept aimed at exploiting Gamma-Ray Bursts for investigating the early Universe and at providing a substantial advancement of multi-messenger and time-domain astrophysics. These goals will be achieved through a unique combination of instruments allowing GRB and X-ray transient detection over a broad field of view (more than 1sr) with 0.5¿1 arcmin localization, an energy band extending from several MeV down to 0.3¿keV and high sensitivity to transient sources in the soft X-ray domain, as well as on-board prompt (few minutes) follow-up with a 0.7¿m class IR telescope with both imaging and spectroscopic capabilities. THESEUS will be perfectly suited for addressing …

Calibration of the photon spectrometer PHOS of the ALICE experiment

Journal of Instrumentation 14(05), P05025 - P05025 (2019). doi:10.1088/1748-0221/14/05/P05025

Assessing and accessing the small airways; implications for asthma management

Despite the wealth of experience in the management of asthma, the disease remains inadequately controlled in some patients, who face long-term respiratory impairment and disability. The disease has been characterised as an inflammatory condition affecting first the larger airways and eventually the smaller airways, but there is evidence that peripheral airway involvement defines a particular and more severe phenotype of asthma. For this reason, assessing functional and biological parameters reflective of small airways involvement is important prognostically. No assessment method is universally and directly representative of peripheral airway function, but the traditional spirometric tests, …

Characterizing the initial conditions of heavy-ion collisions at the LHC with mean transverse momentum and anisotropic flow correlations

Physics letters / B 834, 137393 (2022). doi:10.1016/j.physletb.2022.137393