0000000001006099

AUTHOR

Dirk J. Richel

showing 2 related works from this author

Final results of the European Advanced Renal Cell Carcinoma Sorafenib (EU-ARCCS) expanded-access study: a large open-label study in diverse community…

2011

Background The European Advanced Renal Cell Carcinoma Sorafenib (EU-ARCCS) expanded-access study provided sorafenib to advanced renal cell carcinoma (RCC) patients in whom previous systemic therapy had failed. The study assessed the safety and use of sorafenib for the treatment of advanced RCC in a large community-based patient population across 11 countries in Europe. Patients and methods EU-ARCCS was a single-arm, open-label trial of sorafenib in advanced RCC patients. End points included safety, time to progression, progression-free survival (PFS), and disease control rate (DCR). Subgroup analyses included age, Eastern Cooperative Oncology Group performance status, histology, prior thera…

OncologySorafenibAdultCompassionate Use TrialsMaleNiacinamidemedicine.medical_specialtyAdolescentPyridinesPopulationAntineoplastic Agentsurologic and male genital diseasesDisease-Free SurvivalRenal cell carcinomaInternal medicinemedicineCarcinomaHumanseducationCarcinoma Renal CellneoplasmsAgedNeoplasm StagingAged 80 and overeducation.field_of_studybusiness.industryPhenylurea CompoundsBenzenesulfonatesAge FactorsHematologyMiddle AgedSorafenibmedicine.diseaseRashKidney Neoplasmsfemale genital diseases and pregnancy complicationsSurgeryClinical trialEuropeTreatment OutcomeOncologyTolerabilityExpanded accessFemalemedicine.symptombusinessmedicine.drug
researchProduct

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity.

2008

Colon carcinoma is one of the leading causes of death from cancer and is characterized by a heterogenic pool of cells with distinct differentiation patterns. Recently, it was reported that a population of undifferentiated cells from a primary tumor, so-called cancer stem cells (CSC), can reconstitute the original tumor on xenotransplantation. Here, we show that spheroid cultures of these colon CSCs contain expression of CD133, CD166, CD44, CD29, CD24, Lgr5, and nuclear β-catenin, which have all been suggested to mark the (cancer) stem cell population. More importantly, by using these spheroid cultures or freshly isolated tumor cells from multiple colon carcinomas, we now provide compelling…

Cellular differentiationPopulationmultilineage differentationCell SeparationAdenocarcinomaTissue Culture TechniquesPhosphatidylinositol 3-KinasesCancer stem cellBiomarkers TumormedicineHumansCell LineageeducationProtein Kinase InhibitorsPhosphoinositide-3 Kinase Inhibitorseducation.field_of_studyMultidisciplinarybiologyCD44LGR5Cell DifferentiationBiological Sciencesmedicine.diseasePrimary tumorCell biologyIsolated Tumor CellsColonic NeoplasmsNeoplastic Stem Cellsbiology.proteinStem cell
researchProduct