0000000001008034
AUTHOR
R. Pascale
Ceftolozane/Tazobactam for Treatment of Severe ESBL-Producing
Abstract Background Few data are reported in the literature about the outcome of patients with severe extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections treated with ceftolozane/tazobactam (C/T), in empiric or definitive therapy. Methods A multicenter retrospective study was performed in Italy (June 2016–June 2019). Successful clinical outcome was defined as complete resolution of clinical signs/symptoms related to ESBL-E infection and lack of microbiological evidence of infection. The primary end point was to identify predictors of clinical failure of C/T therapy. Results C/T treatment was documented in 153 patients: pneumonia was the most common diagnosis (n = 46…
Towards a reduction of greenhouse gas emission from wastewater treatment plants: a new plant wide experimental and modelling approach
The increasing interest in greenhouse gas (GHG) emissions from wastewater treatment plants (WWTPs) has led to the development of new tools for their design and management. Studies about gas emissions show that the sewer collection and the wastewater treatment plant are anthropogenic GHG potential sources, so they contribute to the climate change and air pollution. A wastewater treatment plant receives wastewater from sewers and, while produces treated water for discharge into surface water, emits the three major greenhouse gases, CO2, CH4, and N2O, during the treatment processes, and additional amounts of CO2 and CH4 from the energy demands (Bani Shahabadi et al., 2009). Indeed, energy cons…