0000000001008760

AUTHOR

E. Erdal

showing 3 related works from this author

DARWIN: Towards the ultimate dark matter detector

2016

DARk matter WImp search with liquid xenoN (DARWIN) will be an experiment for the direct detection of dark matter using a multi-ton liquid xenon time projection chamber at its core. Its primary goal will be to explore the experimentally accessible parameter space for Weakly Interacting Massive Particles (WIMPs) in a wide mass-range, until neutrino interactions with the target become an irreducible background. The prompt scintillation light and the charge signals induced by particle interactions in the xenon will be observed by VUV sensitive, ultra-low background photosensors. Besides its excellent sensitivity to WIMPs above a mass of 5 GeV/c2, such a detector with its large mass, low-energy …

Physics - Instrumentation and DetectorsPhysics::Instrumentation and Detectorsdouble beta decay7. Clean energy01 natural sciencesHigh Energy Physics - ExperimentPhysics Particles & FieldsNeutrino detectorHigh Energy Physics - Experiment (hep-ex)XenonWIMPPHOTOMULTIPLIERAXIONSphysics.ins-detsolar and atmospheric neutrinosPhysicsDark matter detectorTime projection chamberdark matter detectorsPhysicsSolar and atmospheric neutrinoInstrumentation and Detectors (physics.ins-det)Nuclear & Particles PhysicsNeutrino detectorSOLAR NEUTRINOSGASPhysical SciencesNeutrinoAstrophysics - Instrumentation and Methods for AstrophysicsGRAN SASSODark matter detectors; Double beta decay; Neutrino detectors; Solar and atmospheric neutrinosDark matterchemistry.chemical_elementFOS: Physical sciencesAstronomy & AstrophysicsLIQUID-XENON DETECTOR0202 Atomic Molecular Nuclear Particle And Plasma PhysicsSettore FIS/05 - Astronomia e AstrofisicaSEARCH0103 physical sciencesIsotopes of xenonZEPLIN-III[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]010306 general physicsAxionInstrumentation and Methods for Astrophysics (astro-ph.IM)Science & Technology010308 nuclear & particles physicshep-exAstronomyAstronomy and Astrophysics0201 Astronomical And Space ScienceschemistryHigh Energy Physics::ExperimentSCINTILLATIONneutrino detectorsastro-ph.IMJournal of Cosmology and Astroparticle Physics
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Activation and Inactivation of Tetanus Toxin in Chromaffin Cells

1993

Tetanus toxin is produced by Clostridium tetani as a single chain, almost non-toxic, protein with a molecular weight of approximately 150.000 representing 1315 amino acids. Bacterial proteases cleave the molecule between positions A 457 and S 458 (extracellular activation), yielding a heavy chain (MW 100.000) and a light chain (MW 50.000) tetanus toxin (HC-TeTx, LC-TeTx). Both chains remain connected to each other by a disulphur bond between positions C 439 and C 467 (Dichain-TeTx)1. The cleavage or nicking dramatically increases the biological activity2. HC-TeTx is involved in binding DC-TeTx to gangliosides lodged in the plasma membrane, which is a prerequisite for incorporation into the …

education.field_of_studyClostridium tetaniChemistryPopulationEndocytosismedicine.disease_causeExocytosisCytosolmedicine.anatomical_structureChromaffin cellmedicineExtracellularBiophysicseducationIntracellular
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Processing of tetanus and botulinum A neurotoxins in isolated chromaffin cells.

1995

Tetanus and botulinum A neurotoxins were introduced into the cytosol of chromaffin cells by means of an electric field in which the plasma membrane is forced to form pores of approximately 1 micron at the sites facing the electrodes. As demonstrated by electron microscopy, both [125I] and gold-labelled tetanus toxin (TeTx) diffuse through these transient openings. Dichain-TeTx, with its light chain linked to the heavy chain by means of a disulfide bond, causes the block of exocytosis to develop more slowly than does the purified light chain. The disulfide bonds, which in both toxins hold the subunits together, were cleaved by the intrinsic thioredoxin-reductase system. Single chain TeTx, in…

ProteasesBotulinum ToxinsCell Membrane PermeabilityProteolysisImmunoglobulin light chainmedicine.disease_causeExocytosisExocytosisTetanus ToxinmedicinePeptide bondAnimalsCells CulturedPharmacologymedicine.diagnostic_testToxinChemistryGeneral MedicineCytosolMicroscopy ElectronElectroporationBiochemistryAdrenal MedullaBiophysicsMicroscopy Electron ScanningCattleIntracellularNaunyn-Schmiedeberg's archives of pharmacology
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