0000000001010890
AUTHOR
P. Pagliaro
Inverting Multiple Residual Stress Components from Multiple Cuts with the Contour Method
An extension of the contour method is presented which allows the measurement of multiple stress components by making multiple cuts. In the contour method, a body is carefully cut in two using wire electric discharge machining (EDM). The contours, or shapes, of the cut surfaces are then measured and used to calculate the original residual stress normal to the cut plane using a simple finite element calculation. In the extension presented here, the two pieces from the original body can be cut again in a transverse direction, and the contours of the new cut surfaces are measured. The stresses calculated on the planes of these second cuts have been affected by the first cut. Then a simple inver…
Cardioprotection by gene therapy: A review paper on behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology
Ischemic heart disease remains the leading cause of death worldwide. Ischemic pre-, post-, and remote conditionings trigger endogenous cardioprotection that renders the heart resistant to ischemic-reperfusion injury (IRI). Mimicking endogenous cardioprotection by modulating genes involved in cardioprotective signal transduction provides an opportunity to reproduce endogenous cardioprotection with better possibilities of translation into the clinical setting. Genes and signaling pathways by which conditioning maneuvers exert their effects on the heart are partially understood. This is due to the targeted approach that allowed identifying one or a few genes associated with IRI and cardioprote…