0000000001011207
AUTHOR
H. Osman
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis and sepsis clinical presentation can be extremely low. This study evaluated the sensitivity and specificity of currently used commercial and in‐house diagnostic and typing assays. Accurately quantified RNA transcript controls were distributed to 27 diagnostic and 12 reference laboratories in 17 European countries for blinded testing. Transcripts represented the four human EV…
Elicitins trap and transfer sterols from micelles, liposomes and plant plasma menbranes
International audience
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…
Effects of 12 beticolins, Cercospora beticola toxins, on proliferation of ras-transformed adrenocortical cell
International audience
Combination of the novel farnesyltransferase inhibitor RPR 130401 and the gerannylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G1-S transition in Ki-Ras-overexpressing transformed adrenocortical cells
International audience
Géranylgéranylation et farnésylation des protéines Ras dans les cellules corticosurrénales transformées par l'oncogène rasEJ; l'effet antiprolifératif de la déhydroépiandrostérone (DHEA) est-il lié à l'inhibition de l'isoprénylation?
150 ref. *INRA Dijon, Documentation, 17 rue Sully, BP 86510, 21065 Dijon cedex Diffusion du document : INRA Dijon, Documentation, 17 rue Sully, BP 86510, 21065 Dijon cedex Diplôme : Dr. d'Université
Geranylgeranyl as well as farnesyl moiety is transferred to Ras p21 overproduced in adrenocortical cells transformed by c-Ha-ras oncogene
International audience