0000000001012573

AUTHOR

Else Dapat

showing 2 related works from this author

Biopiracy of natural products and good bioprospecting practice

2016

Made available in DSpace on 2018-11-26T16:27:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-02-15 Deutsche Forschungsgemeinschaft Background: Biopiracy mainly focuses on the use of biological resources and/or knowledge of indigenous tribes or communities without allowing them to share the revenues generated out of economic exploitation or other non-monetary incentives associated with the resource/knowledge. Methods: Based on collaborations of scientists from five continents, we have created a communication platform to discuss not only scientific topics, but also more general issues with social relevance. This platform was termed 'PhytCancer -Phytotherapy to Fight Cancer' (www.phy…

0301 basic medicineResource (biology)Drug IndustryInternational CooperationTheftPharmaceutical ScienceIntellectual property0603 philosophy ethics and religionIndigenousPatents as Topic03 medical and health sciencesIndigenous knowledgeDrug DiscoveryPatents as TopicTraditional knowledgeDeveloping CountriesPharmacologyBioprospectingBiological ProductsBioprospectingPlants Medicinalbusiness.industryIntellectual propertyCommercializationOwnership06 humanities and the artsPublic relationsBioethicsNatural resource030104 developmental biologyIncentiveComplementary and alternative medicineEthnopharmacologyMolecular MedicinePatent060301 applied ethicsBusiness
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Substrate Specificity of Aglaia loheri Active Isolate towards P-glycoprotein in Multidrug-Resistant Cancer Cells

2016

Multidrug resistance (MDR) is a major contributory factor in the failure of chemotherapy. Concrete interpretation of P-glycoprotein (P-gp) substrate specificity, whether a substance is a substrate or an inhibitor, represents an important feature of a compound's pharmaceutical profiling in drug design and development. In this work, the P-gp substrate specificity of Maldi 531.2[M+H]+, a phenol ester from Aglaia loheri Blanco leaves was investigated. This study focuses on the effect of Maldi 531.2[M+H]+ on P-gp ATPase activity, which was examined by measuring the amount of inorganic phosphates (Pi) released as a result of ATP hydrolysis. To test the effects of Maldi 531.2[M+H]+ on MDR activit…

0301 basic medicinePharmacologybiologyChemistryStereochemistryStimulationPlant ScienceGeneral MedicineMultiple drug resistance03 medical and health sciences030104 developmental biology0302 clinical medicineNon-competitive inhibitionComplementary and alternative medicineATP hydrolysis030220 oncology & carcinogenesisDrug DiscoveryCancer cellmedicinebiology.proteinPiVerapamilmedicine.drugP-glycoproteinNatural Product Communications
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