0000000001034095
AUTHOR
Calogero Stelletta
Anomalous water dynamics in brain: a combined diffusion magnetic resonance imaging and neutron scattering investigation
International audience; Water diffusion is an optimal tool for investigating the architecture of brain tissue on which modern medical diagnostic imaging techniques rely. However, intrinsic tissue heterogeneity causes systematic deviations from pure free-water diffusion behaviour. To date, numerous theoretical and empirical approaches have been proposed to explain the non-Gaussian profile of this process. The aim of this work is to shed light on the physics piloting water diffusion in brain tissue at the micrometre-to-atomic scale. Combined diffusion magnetic resonance imaging and first pioneering neutron scattering experiments on bovine brain tissue have been performed in order to probe dif…
Water Dynamics in Neural Tissue
Water dynamics in post-mortem two-years old bovine cerebral right hemisphere has been investigated through Elastic and Quasi-elastic Neutron Scattering. Experimental parameters such as stability in time of the proton dynamics, data reproducibility and changes in the tissues dynamics upon the conservation protocol, cryogenic towards formalin addition, have been carefully investigated. Results are extremely encouraging and comparisons to magnetic resonance imaging findings are discussed.