Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice
In the present study, the possibility that a diabetic (DM) status might worsen age-related bone deterioration was explored in mice. Male CD-1 mice aged 2 (young control group) or 16 months, nondiabetic or made diabetic by streptozotocin injections, were used. DM induced a decrease in bone volume, trabecular number, and eroded surface, and in mineral apposition and bone formation rates, but an increased trabecular separation, in L1-L3 vertebrae of aged mice. Three-point bending and reference point indentation tests showed slight changes pointing to increased frailty and brittleness in the mouse tibia of diabetic old mice. DM was related to a decreased expression of both vascular endothelial …
Personal Exposure to Ultrafine Particles According to Different Environments and Modes of Transport in Schoolchildren: Results from a Spanish Cohort in Valencia
Background Combustion, especially in diesel engines, emits a complex mixture of gases and particles that could be harmful for the respiratory and cardiovascular systems. Daily personal exposure to the smallest particulate matter (less than 0.1 µm and usually called nanoparticles or ultrafine particles – UFP) has been studied to a lesser extent compared to coarser particles. In this study we aim to assess personal exposure to UFP in different environments and transport modes among schoolchildren from a Spanish birth-cohort in the province of Valencia. Methods The study population consisted of 114 children aged 10-11 years. For each of them, personal exposure to UFP was measured continuously …