0000000001037267
AUTHOR
Luis Corrales
Second-Line Treatment of Non-Small Cell Lung Cancer: Clinical, Pathological, and Molecular Aspects of Nintedanib
Abstract: Lung carcinoma is the leading cause of death by cancer in the world. Nowadays, most patients will experience disease progression during or after first-line chemotherapy demonstrating the need for new, effective second-line treatments. The only approved second-line therapies for patients without targetable oncogenic drivers are docetaxel, gemcitabine, pemetrexed, and erlotinib and for patients with target-specific oncogenes afatinib, osimertinib, crizotinib, alectinib, and ceritinib. In recent years, evidence on the role of antiangiogenic agents have been established as important and effective therapeutic targets in non-small cell lung cancer (NSCLC). Nintedanib is a tyrosine kinas…
Morphological and Biometric Features of Male BluethroatsLuscinia svecicain Central Iberia
Summary. In order to test biometrics and plumage variability in bluethroats Luscinia svecica in central Iberia, 185 birds were captured in four areas (Sierra-Bejar, Sierra-Piedrahita, Sierra-Gredos and Sierra-Paramera). Older bluethroats were significantly larger than second calendar year birds in wing, tail, and total body lengths, but not in tarsus and bill lengths. A multivariate analysis of variance (MANOVA) and a principal component analysis (PCA) were used. Total body length only varied significantly between sampling areas: the birds from Sierra-Bejar were larger than those from Sierra-Gredos and Sierra-Paramera, but were similar to those of Sierra-Piedrahita. Birds with a white spot,…