0000000001037992

AUTHOR

Esa Kuismanen

showing 1 related works from this author

Mobilization of late-endosomal cholesterol is inhibited by Rab guanine nucleotide dissociation inhibitor

2000

AbstractCholesterol entering cells in low-density lipoproteins (LDL) via receptor-mediated endocytosis is transported to organelles of the late endocytic pathway for degradation of the lipoprotein particles. The fate of the free cholesterol released remains poorly understood, however. Recent observations suggest that late-endosomal cholesterol sequestration is regulated by the dynamics of lysobisphosphatidic acid (LBPA)-rich membranes [1]. Genetic studies have pinpointed a protein, Niemann–Pick C-1 (NPC-1), that is required for the mobilization of late-endosomal/lysosomal cholesterol by an unknown mechanism [2]. Here, we report the removal of accumulated cholesterol by overexpression of the…

HydrolasesEndosomeEndocytic cycleEndosomesCholesterol 7 alpha-hydroxylaseGeneral Biochemistry Genetics and Molecular BiologyCell Line03 medical and health scienceschemistry.chemical_compound0302 clinical medicineHumansGuanine Nucleotide Dissociation Inhibitors030304 developmental biologyNiemann-Pick Diseases0303 health sciencesbiologyAgricultural and Biological Sciences(all)CholesterolBiochemistry Genetics and Molecular Biology(all)Reverse cholesterol transportCholesterol LDLEndocytosisRecombinant ProteinsCell biologyCholesterolchemistryBiochemistryHMG-CoA reductasebiology.proteinMonoglycerideslipids (amino acids peptides and proteins)RabLysophospholipidsLysosomesGeneral Agricultural and Biological Sciences030217 neurology & neurosurgeryLipoproteinCurrent Biology
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