0000000001045823
AUTHOR
Sabrina Kellouche
Study of fibrosis induced by an implanted medical device
National audience; This paper focuses on the study of fibrosis induced by an implanted medical device and explores the possibility of characterizing this process by in situ measurement of electrical impedance. The approach combines electrical and biological characterizations of fibrotic tissue, applied to electrodes implanted in animal models. A comparative study of electrical and biological parameters collected at the same time will enable the identification of an electrical marker of fibrosis development, which can be used for establishing a monitoring method. Adopting an interdisciplinary approach, intermediate embedded prototypes, autonomous and portable by animals, will be developed to…
Shell Extracts from the Marine Bivalve Pecten maximus Regulate the Synthesis of Extracellular Matrix in Primary Cultured Human Skin Fibroblasts
International audience; Mollusc shells are composed of more than 95% calcium carbonate and less than 5% of an organic matrix consisting mostly of proteins, glycoproteins and polysaccharides. Previous studies have elucidated the biological activities of the shell matrices from bivalve molluscs on skin, especially on the expression of the extracellular matrix components of fibroblasts. In this work, we have investigated the potential biological activities of shell matrix components extracted from the shell of the scallop Pecten maximus on human fibroblasts in primary culture. Firstly, we demonstrated that shell matrix components had different effects on general cellular activities. Secondly, …