0000000001059582

AUTHOR

Ishaiahu Shechter

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Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids

2005

Dietary vegetable oils and fish oils rich in PUFA (polyunsaturated fatty acids) exert hypocholesterolaemic and hypotriglyceridaemic effects in rodents. The plasma cholesterol-lowering properties of PUFA are due partly to a diminution of cholesterol synthesis and of the activity of the rate-limiting enzyme HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase). To better understand the mechanisms involved, we examined how tuna fish oil and individual n−3 and n−6 PUFA affect the expression of hepatic FPP synthase (farnesyl diphosphate synthase), a SREBP (sterol regulatory element-binding protein) target enzyme that is subject to negative-feedback regulation by sterols, in co-ordination …

RNA StabilityBlotting WesternDown-RegulationReductaseBiochemistryGene Expression Regulation EnzymologicMicechemistry.chemical_compoundFish OilsFarnesyl diphosphate synthaseCell Line TumorAnimalsHumansRNA MessengerPromoter Regions GeneticMolecular BiologyTriglyceridesCell Nucleuschemistry.chemical_classificationAlkyl and Aryl TransferasesbiologyTunaCholesterolalpha-Linolenic acidalpha-Linolenic Acidfood and beveragesGeranyltranstransferaseCell BiologyHydroxymethylglutaryl-CoA reductaseEicosapentaenoic acidDietRatsDNA-Binding ProteinsCholesterolLiverchemistryBiochemistryDocosahexaenoic acidCCAAT-Enhancer-Binding ProteinsFatty Acids Unsaturatedbiology.proteinHydroxymethylglutaryl CoA Reductaseslipids (amino acids peptides and proteins)Sterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding Protein 2Transcription FactorsResearch ArticlePolyunsaturated fatty acidBiochemical Journal
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