Micro-RNA segnature of human hepatocellular carcinoma

2008

Natural immunity in Paracentrotus lividus: coelomocyte cooperation

2005

Solid-lipid nanoparticles for gene delivery to cells.

2006

New trends in overcoming drug resistance in hepatocellular carcinoma. Looking for pharmacological inhibition of Inhibitory of Apoptosis Proteins (IAP…

2005

Rsponse to antiviral therapy and hepatic expression of cycloossogenases in chronic hepatitis C.

2006

First evidences of Toll like receptor on Paracentrotus livisua coelomocytes.

2004

Hepatic expression of cycloxygenase-2 in non-alcoholic fatty liver disease

2008

NANOPARTICELLE LIPIDICHE SOLIDE CATIONICHE COME VETTORI NON VIRALI DEL DNA

2007

PIVKAII Utility in Diagnosis and Post-therapeutic Monitoring of Hepatocellular Carcinoma

Background: Protein induced by vitamin K absence (PIVKA-II), also known as des-gamma-carboxyprothrombin, has been described in relation to HCC being released in association with vitamin K deficiency in the presence of HCC. Serum alpha-fetoprotein (AFP) is the traditional biomarker for HCC detection and follow up but it doesn’t have high sensitivity and specificity. Therefore, there is great interest in identifying new more powerful biomarkers. Materials and methods: One hundred and fourteen subjects were divided into four groups: Group 1 included 58 patients (38M, 20 F) with HCC, mean age 73.5; Group 2 included 38 patients (28M, 10F) with liver cirrhosis (LC), mean age 63.7; Group 3 include…

Antitumor effects of curcumin, alone or in combination with cisplatin, on hepatic cancer cells. Analysis of their relationship to IL-6 production

2005

Response to antiviral therapy and hepatic expression of cycloxigenases in chronic hepatitis C

2006

Risposta alla terapia antivirale ed espressione epatica della ciclossigenasi nell’epatite C

2006

VEGFR-2, HSP90 and GRP78/BiP expression and HCC recurrence after Liver Transplantation

2018

Introduction Liver transplantation (LT) for hepatocellular carcinoma (HCC) is a satisfactory therapeutic choice in patients with “early HCC” selected according to Milan criteria. However, the risk of HCC recurrence after LT is about 7-20% at five years and molecular markers which can predict recurrence are still lacking. We investigated in HCC samples and LC surrounding tissues the significance of VEGFR-2, HSP90, and GRP78/BiP expression in patients with HCC who underwent LT in a western transplantation center and their possible role as molecular markers of recurrence. Methods 42 patients (35 M, 7 F) with early HCC who underwent LT between 2012 and 2013 were enrolled. The tumor recurrence r…

"Antitumor effects of the novel NF-kB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) on human hepatic cancer cells: analysis of synergy with cispla…

2006

We tested the novel NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in the hepatic cancer (HCC) HepG2, HA22T/VGH and HuH-6 cells. The sensitivity to the cell growth inhibitory and apoptotic effects of the agent increased along with the levels of constitutively activated NF-kappaB, which were low in HepG2 and higher in HA22T/VGH and HuH-6. In HA22T/VGH, DHMEQ exhibited synergy with cisplatin. In the same cells, DHMEQ exerted dose-dependent decreases in the nuclear levels of activated NF-kappaB and attenuated NF-kappaB activation by cisplatin. It down-regulated Bcl-XL mRNA in a dose-dependent manner and up-regulated that of Bcl-XS. It also decreased interleukin 6 (IL-6), NAIP and, …

Cationic solid-lipid nanoparticles for gene delivery.

2006

Antitumor effects of the NF-kB inhibitors curcumin and DHMEQ, alone or combined with cisplatin, on hepatic cancer cells. analysis of their relationsh…

2005

The selective COX-1 inhibitor SC-560 suppresses cell growth and induces apoptosis in human hepatocellular carcinoma cells

2005

Circulating E-selectin levels in chronic hepatitis C patients with normal or elevated transaminase before and after alpha-interferon treatment

2001

E-selectin, an adhesion molecule of the selectin family, is involved in leukocyte adhesion to the endothelium and in the cellular immunological reactions. Expression of this molecule, in fact, is physiologically absent, but it becomes evident on sinusoidal lining cells during inflammatory liver disease. The aim of this study was to evaluate the behavior of E-selectin in chronic hepatitis C (CH-C) patients with persistently normal transaminase in comparison to patients with CH-C and elevated transaminase, and its changes during alpha-interferon therapy. Immunohistochemical localization of E-selectin was also performed on liver tissue specimens of both groups. Fifty-eight subjects were divide…