0000000001062468
AUTHOR
P Proia
CONSEQUENCES OF AAS DOPING: AN OVERVIEW OF SHORT AND LONG TERM EFFECTS
AAS, if taken in overphysiological doses, may increase muscle strenght and lean body mass, while they don't seem to have effects on endurance performance and on fat mass. Because of the widespread use of these substances, the focus is on their related side effects. The effects on the reproductive system seem to be quite important and they may induce some changes as far as libido and (temporary) infertility are concerned. In recent years it has become clear that AAS can have significant impacts on psyche and behaviour. Researches and future studies should focus their attention primarily on the short and long term effects due to the discontinuous use of AAS and on the long term health effects…
Semaphorin 4D cooperates with VEGF to promote angiogenesis and tumor progression
The semaphorins and plexins comprise a family of cysteine-rich proteins implicated in control of nerve growth and development and regulation of the immune response. Our group and others have found that Semaphorin 4D (SEMA4D) and its receptor, Plexin-B1, play an important role in tumor-induced angiogenesis, with some neoplasms producing SEMA4D in a manner analogous to vascular endothelial growth factor (VEGF) in order to attract Plexin-B1-expressing endothelial cells into the tumor for the purpose of promoting growth and vascularity. While anti-VEGF strategies have been the focus of most angiogenesis inhibition research, such treatment can lead to upregulation of pro-angiogenic factors that …
Detection of exercise adaptations by different specimens analysis
This literature review is a compilation of the most used methods to monitoring athletes in training and competition. Blood is certainly the best known and proven methodology and a wide range of markers can be analyzed through it, but it can be difficult to obtain, especially among athletes or people who are afraid of needles. The use of saliva is an interesting alternative especially for the easy and less invasive method of collecting. The saliva infact contains a few of compounds diffused in the plasma, like water, electrolytes, proteins, metabolites and hormones. However, new methods yet poorly understood are slowly catching on; sweat for example, may carry far more information, may provi…
Effects of combined exercise on psychological and physiological variables in cancer patients: A pilot study
Purpose: The aim of this study was to investigate the effect of a short-term combined exercise intervention program on perceived self-efficacy, fatigue, lower back flexibility, balance and task specific functional mobility in cancer patients. Materials and Methods: Fifteen patients met all the eligibility criteria and were assigned to a single training group (range age, 22-75 years) that performed an 8-week intervention program (∼60min, 2dwk-1). Each session included a progressive training of cardiorespiratory, resistance, flexibility and postural education exercises. Measures pre-intervention and post-intervention included psychological and physiological measurements. Adherence to training…