0000000001083029

AUTHOR

Ann M. Haberman

showing 2 related works from this author

Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool.

2015

Tissue homeostasis is achieved through a balance of cell production (growth) and elimination (regression). In contrast to tissue growth, the cells and molecular signals required for tissue regression remain unknown. To investigate physiological tissue regression, we use the mouse hair follicle, which cycles stereotypically between phases of growth and regression while maintaining a pool of stem cells to perpetuate tissue regeneration. Here we show by intravital microscopy in live mice that the regression phase eliminates the majority of the epithelial cells by two distinct mechanisms: terminal differentiation of suprabasal cells and a spatial gradient of apoptosis of basal cells. Furthermor…

Intravital MicroscopyApoptosisBiologyAnimals; Apoptosis; Dermis; Epithelial Cells; Hair Follicle; Homeostasis; Mice; Phagocytes; Regeneration; Signal Transduction; Stem Cell Niche; Stem Cells; Transforming Growth Factor beta; beta Catenin; Cell Death; Phagocytosis; Medicine (all); MultidisciplinaryArticleMicePhagocytosisStem CellTransforming Growth Factor betaHomeostasimedicineAnimalsHomeostasisRegenerationStem Cell NicheTissue homeostasisbeta CateninEpithelial CellPhagocytosiPhagocytesMultidisciplinaryCell DeathAnimalRegeneration (biology)Medicine (all)Stem CellsMesenchymal stem cellApoptosiEpithelial CellsTransforming growth factor betaDermisHair follicleEpitheliumCell biologymedicine.anatomical_structurePhagocytebiology.proteinDermiStem cellHair FollicleTransforming growth factorSignal TransductionNature
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Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration

2012

Tissue development and regeneration depend on cell-cell interactions and signals that target stem cells and their immediate progeny. However, the cellular behaviours that lead to a properly regenerated tissue are not well understood. Using a new, non-invasive, intravital two-photon imaging approach we study physiological hair-follicle regeneration over time in live mice. By these means we have monitored the behaviour of epithelial stem cells and their progeny during physiological hair regeneration and addressed how the mesenchyme influences their behaviour. Consistent with earlier studies, stem cells are quiescent during the initial stages of hair regeneration, whereas the progeny are more …

MesodermCell divisionCell SurvivalMesenchymeMice TransgenicBiologyArticleMesodermMiceCell MovementStem CellLive cell imagingmedicineAnimalsRegenerationMultidisciplinaryintegumentary systemAnimalStem CellsMedicine (all)Regeneration (biology)DermisHair follicleCell biologyMicroscopy Fluorescence Multiphotonmedicine.anatomical_structureAnimals; Cell Division; Cell Movement; Cell Survival; Cell Tracking; Dermis; Hair Follicle; Laser Therapy; Mesoderm; Mice; Mice Transgenic; Microscopy Fluorescence Multiphoton; Regeneration; Stem Cells; Medicine (all); MultidisciplinaryCell TrackingDermiLaser TherapyStem cellHair FollicleDevelopmental biologyCell DivisionNature
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