0000000001088868

AUTHOR

Paula Mcclean

showing 2 related works from this author

An Early Stage Researcher's Primer on Systems Medicine Terminology

2021

Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. Thes…

computer_scienceGraphs and NetworksmedicineGlossary[SDV]Life Sciences [q-bio]Comprehensive ReviewTerminology03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingMachine learningGeneticsmultiscale data science[INFO]Computer Science [cs]systems medicinemulti-scale modellingMulti-scale modellingComputingMilieux_MISCELLANEOUS030304 developmental biologyInterdisciplinarityMulti-scale data science0303 health scienceshealthGeneral MedicineHuman bodySciences bio-médicales et agricolesData science[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]multiscale modeling3. Good healthTerm (time)Systems medicinemachine learningmulti-scale data scienceSystems medicineMedicine/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being030217 neurology & neurosurgeryNetwork and Systems Medicine
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Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™.

2015

OBJECTIVE: Cerebral microvascular impairments occurring in AD may reduce Aβ peptide clearance and impact upon circulatory ultrastructure and function. We hypothesized that microvascular pathologies occur in organs responsible for systemic Aβ peptide clearance in a model of AD and that Liraglutide (Victoza(®)) improves vessel architecture. METHODS: Seven-month-old APP/PS1 and age-matched wild-type mice received once-daily intraperitoneal injections of either Liraglutide or saline (n = 4 per group) for eight weeks. Casts of cerebral, splenic, hepatic, and renal microanatomy were analyzed using SEM. RESULTS: Casts from wild-type mice showed regularly spaced microvasculature with smooth lumenal…

medicine.medical_specialtyPhysiologySpleenMice TransgenicKidneyMicrocirculationAmyloid beta-Protein PrecursorMiceAlzheimer DiseaseGlucagon-Like Peptide 1Physiology (medical)Internal medicinemedicinePresenilin-1AnimalsHumansHypoglycemic AgentsMolecular BiologyKidneybusiness.industryLiraglutideMicrocirculationBrainLiraglutideGlucagon-like peptide-1Extravasationmedicine.anatomical_structureEndocrinologyCerebrovascular CirculationCirculatory systemMicrovesselsSystemic administrationCardiology and Cardiovascular MedicinebusinessSpleenmedicine.drugMicrocirculation (New York, N.Y. : 1994)
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