0000000001088909

AUTHOR

Mario Encinas

0000-0003-3509-7431

showing 2 related works from this author

Differential Gene Expression of Medullary Thyroid Carcinoma Reveals Specific Markers Associated with Genetic Conditions

2013

Maliszewska, Agnieszka et al.

Pathologymedicine.medical_specialtyendocrine system diseasesInheritance PatternsMultiple endocrine neoplasia type 2ApoptosisBiologyGermlinePathology and Forensic MedicineThyroid carcinomaAntigens CDCell Line TumormedicineBiomarkers TumorGene silencingCluster AnalysisHumansGenetic Predisposition to DiseaseAC133 AntigenGene SilencingThyroid NeoplasmsRNA Small InterferingGlycoproteinsRegulation of gene expressionTissue microarrayReverse Transcriptase Polymerase Chain ReactionGene Expression ProfilingWnt signaling pathwaymedicine.diseaseImmunohistochemistryCarcinoma NeuroendocrineGene expression profilingGene Expression Regulation NeoplasticGene Knockdown TechniquesCancer researchPeptides
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Impaired Vitamin D Signaling in Endothelial Cell Leads to an Enhanced Leukocyte-Endothelium Interplay: Implications for Atherosclerosis Development

2015

Endothelial cell activation leading to leukocyte recruitment and adhesion plays an essential role in the initiation and progression of atherosclerosis. Vitamin D has cardioprotective actions, while its deficiency is a risk factor for the progression of cardiovascular damage. Our aim was to assess the role of basal levels of vitamin D receptor (VDR) on the early leukocyte recruitment and related endothelial cell-adhesion-molecule expression, as essential prerequisites for the onset of atherosclerosis. Knockdown of VDR in endothelial cells (shVDR) led to endothelial cell activation, characterized by upregulation of VCAM-1, ICAM-1 and IL-6, decreased peripheral blood mononuclear cell (PBMC) ro…

Malemedicine.medical_specialtyEndotheliumMedicinalcsh:MedicineDown-RegulationVascular Cell Adhesion Molecule-1InflammationCell CommunicationBiologyCalcitriol receptorCell LineEndothelial activationMiceEndothelial cellNF-KappaB Inhibitor alphaInternal medicineCell AdhesionmedicineAnimalsHumansMacrophageEndotheliumVitamin Dlcsh:ScienceCell adhesionMultidisciplinaryInterleukin-6lcsh:RNF-kappa BEndothelial CellsAtherosclerosisIntercellular Adhesion Molecule-1Plaque AtheroscleroticUp-RegulationMice Inbred C57BLEndothelial stem cellIκBαmedicine.anatomical_structureEndocrinologyLeukocytes MononuclearReceptors Calcitriollcsh:QFemaleI-kappa B Proteinslipids (amino acids peptides and proteins)medicine.symptomSignal TransductionResearch ArticlePLOS ONE
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