Tutor-Sky: A web environment for multimedia on-line education

Computer Science and Telecommunication technologies are being more and more integrated in teaching and learning systems. The subsequent modification of the educational world becomes a natural event towards a student who is immersed in a multimedia technological society and expects to find a similar learning environment. At present, multimedia is widely used in education to improve and integrate the learning processes and is ever more used in on-line education where the different media help in re-creating the “natural” interaction between teachers and students. There are many tools that allow creation and publication on web of learning contents, but none of them allows teachers to easily and…

Synthesis of Fluorinated Bent-Core Mesogens (BCMs) Containing the 1,2,4-Oxadiazole Ring

New fluorinated bent-core mesogens containing the 1,2,4-oxadiazole or 1,2,4-triazole nucleus have been synthesized taking advantage of the ANRORC (Addition of Nucleophile, Ring-Opening, Ring-Closure) reactivity of 5-perfluoroalkyl-1,2,4-oxadiazoles. Physical state changes of the obtained compounds were characterized through DSC, POM, and SAXS. Besides the formation of a smectic mesophase, a novel behavior as organic molecular glass was evidenced for some 1,2,4-oxadiazole derivatives.

Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells

Efficacy, safety and tolerability of combined low-dose simvastatin-fenofibrate treatment in primary mixed hyperlipidaemia.

In order to assess the long-term (12 months) efficacy and safety of fenofibrate administered with simvastatin in the treatment of primary mixed hyperlipidaemia, we conducted a study that compared increasing dosages of these drugs in subgroups of men and women belonging to a clinical sample of outpatients. This was an open study carried out in patients with primary mixed hyperlipidaemia (lipoprotein phenotype IIb) who needed a combined therapeutic approach because of their poor response to a single-drug regimen with an HMG-CoA reductase inhibitor (simvastatin). Thus, a fibrate (fenofibrate) was added to the therapy. The study lasted 12 months. Forty-five patients (mean age: 58.9 ± 11.3 years…

Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells

Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells

Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells Laura Lentini, Raffaella Melfi, Sara Baldassano, Marco Tutone, Aldo Di Leonardo, Andrea Pace, Ivana Pibiri Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo Background and rationale Cystic Fibrosis patients with nonsense mutations in the CFTR gene have a more severe form of the disease. Nonsense mutations represent about 10% of the mutations that affect the CFTR gene and they are frequently associated to the classical F508 mutation (1). A potential treatment for this genetic alteration is to promote the translationa…

A NEW WATER-SOLUBLE FLUORINATED POLYMER BASED ON A POLYASPARTAMIDE AND OXADIAZOLE UNITS AS A POTENTIAL ARTIFICIAL OXYGEN (O2) CARRIER

Thin-Film Heterojunction by Carbon Nanotube Derivatives with Enhanced Solubility and Optical Properties

Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models

CCDC 633320: Experimental Crystal Structure Determination

Related Article: A.P.Piccionello, I.Pibiri, A.Pace, R.A.Raccuglia, S.Buscemi, N.Vivona, G.Giorgi|2007|Heterocycles|71|1529|doi:10.3987/COM-07-11040

CCDC 621722: Experimental Crystal Structure Determination

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, S.Pappalardo, D.Garozzo, T.Pilati, G.Gattuso, A.Pappalardo, I.Pisagatti, M.F.Parisi|2006|Tetrahedron Lett.|47|9049|doi:10.1016/j.tetlet.2006.10.092

CCDC 633321: Experimental Crystal Structure Determination

Related Article: A.P.Piccionello, I.Pibiri, A.Pace, R.A.Raccuglia, S.Buscemi, N.Vivona, G.Giorgi|2007|Heterocycles|71|1529|doi:10.3987/COM-07-11040

CCDC 271045: Experimental Crystal Structure Determination

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, G.Macaluso, N.Vivona, D.Spinelli, G.Giorgi|2005|J.Org.Chem.|70|3288|doi:10.1021/jo047766s

CCDC 804195: Experimental Crystal Structure Determination

Related Article: A.Terenzi, G.Barone, A.P.Piccionello, G.Giorgi, A.Guarcello, A.Pace|2011|Inorg.Chim.Acta|373|62|doi:10.1016/j.ica.2011.03.057

CCDC 630243: Experimental Crystal Structure Determination

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

CCDC 915396: Experimental Crystal Structure Determination

Related Article: M.Saccone,G.Cavallo,P.Metrangolo,A.Pace,I.Pibiri,T.Pilati,G.Resnati,G.Terraneo|2013|CrystEngComm|15|3102|doi:10.1039/C3CE40268A

CCDC 630242: Experimental Crystal Structure Determination

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

CCDC 653860: Experimental Crystal Structure Determination

Related Article: A.P.Piccionello, A.Pace, S.Buscemi, N.Vivona, M.Pani|2008|Tetrahedron|64|4004|doi:10.1016/j.tet.2008.02.047

CCDC 245638: Experimental Crystal Structure Determination

Related Article: A.Pace, I.Pibiri, S.Buscemi, N.Vivona, L.Malpezzi|2004|J.Org.Chem.|69|4108|doi:10.1021/jo049814e

CCDC 279694: Experimental Crystal Structure Determination

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, N.Vivona, M.Pani|2006|Tetrahedron|62|1158|doi:10.1016/j.tet.2005.10.071

CCDC 279693: Experimental Crystal Structure Determination

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, N.Vivona, M.Pani|2006|Tetrahedron|62|1158|doi:10.1016/j.tet.2005.10.071

CCDC 749593: Experimental Crystal Structure Determination

Related Article: A.Terenzi, G.Barone, A.P.Piccionello, G.Giorgi, A.Guarcello, P.Portanova, G.Calvaruso, S.Buscemi, N.Vivona, A.Pace|2010|Dalton Trans.|39|9140|doi:10.1039/c0dt00266f

CCDC 245639: Experimental Crystal Structure Determination

Related Article: A.Pace, I.Pibiri, S.Buscemi, N.Vivona, L.Malpezzi|2004|J.Org.Chem.|69|4108|doi:10.1021/jo049814e

CCDC 653859: Experimental Crystal Structure Determination

Related Article: A.P.Piccionello, A.Pace, S.Buscemi, N.Vivona, M.Pani|2008|Tetrahedron|64|4004|doi:10.1016/j.tet.2008.02.047

CCDC 915397: Experimental Crystal Structure Determination

Related Article: M.Saccone,G.Cavallo,P.Metrangolo,A.Pace,I.Pibiri,T.Pilati,G.Resnati,G.Terraneo|2013|CrystEngComm|15|3102|doi:10.1039/C3CE40268A

CCDC 635325: Experimental Crystal Structure Determination

Related Article: A.Mugnoli, G.Barone, S.Buscemi, C.Z.Lanza, A.Pace, M.Pani, D.Spinelli|2009|J.Phys.Org.Chem.|22|1086|doi:10.1002/poc.1563

CCDC 630241: Experimental Crystal Structure Determination

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e