0000000001095082
AUTHOR
F. Bartoli
Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy
Background For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. Methods The STAR Network "Depot" Study is an observational, longitudinal…
Comparing Long-Acting Antipsychotic Discontinuation Rates Under Ordinary Clinical Circumstances: A Survival Analysis from an Observational, Pragmatic Study
Background Recent guidelines suggested a wider use of long-acting injectable antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in terms of discontinuation rates and associated factors are still sparse, making it hard for clinicians to be informed on plausible treatment courses. Objective Our objective was to assess, under real-world clinical circumstances, LAI discontinuation rates over a period of 12 months after a first prescription, reasons for discontinuation, and associated factors. Methods The STAR Network ‘Depot Study’ was a naturalistic, multicentre, observational prospective study that enrolled subjects initiating a LAI without restrictions …
Organic matter dynamics and aggregation in soils under rain forest and pastures of increasing age in the eastern Amazon Basin
Abstract In the eastern Amazon basin, four neighbouring clayey Oxisols with similar particle-size distributions were selected, one under rain forest and three under pasture for 7, 12 and 17 years, respectively. These soils were sampled at depth intervals of 0.1 m down to 1 m. Although no clear effect of pasture establishment on aggregate stability was assessed, significant negative effects of cattle trampling on porosity and water retention and of vegetation change on clay water-dispersion were observed in the organic-rich horizons (0–0.40 m layers). Indirect evidence of a great change of the nature of organic materials was also suggested, particularly with (i) an increase in both negative …
Prevalence and correlates of QTc prolongation in Italian psychiatric care: cross-sectional multicentre study.
Aims.In recent years several warnings have been issued by regulatory authorities on the risk of electrocardiogram abnormalities in individuals exposed to psychotropic drugs. As a consequence of these warnings, monitoring of the QT interval corrected for heart rate (QTc) has become increasingly common. This study was conducted to measure the frequency of QTc prolongation in unselected psychiatric patients, and to document the associated factors using a cross-sectional approach.Method.The study was carried out in 35 Italian psychiatric services that are part of the STAR (Servizi Territoriali Associati per la Ricerca) Network, a research group established to produce scientific knowledge by col…
Water-stable aggregates and organic matter pools in a calcareous vineyard soil under four soil-surface management systems
. Vineyards in Champagne, France are generally situated on slopes where the soils are subject to erosion. Therefore it is important to find a soil-surface management practice that protects the soil against water erosion. We assessed the potential of mulches or grass covers to stabilize soil aggregates in a calcareous sandy loam from a vineyard in Champagne after 9 years under different management systems. Four different treatments were studied: (i) a bluegrass (Poa pratensis) surface cover between the vine rows (GC) with bare soil under the vines (R); two organic mulches of (ii) coniferous (CB) or (iii) poplar (PB) bark that covered the entire soil surface, and (iv) bare soil between the ro…